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ACE angiotensin I converting enzyme [ Equus caballus (horse) ]

Gene ID: 100064801, updated on 17-Aug-2024

Summary

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Official Symbol
ACEprovided by VGNC
Official Full Name
angiotensin I converting enzymeprovided by VGNC
Primary source
VGNC:VGNC:58509
See related
Ensembl:ENSECAG00000012910
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See ACE in Genome Data Viewer
Location:
chromosome: 11
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 11 NC_009154.3 (15801253..15840520, complement)

Chromosome 11 - NC_009154.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111775615 Neighboring gene angiotensin-converting enzyme-like protein Ace3 Neighboring gene potassium voltage-gated channel subfamily H member 6 Neighboring gene 60S ribosomal protein L21 pseudogene Neighboring gene cytochrome b561 Neighboring gene tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009154.3 Chromosome 11 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Precompetition angiotensin converting enzyme (ACE) activity in endurance horses competing in an 80 km event was not associated with either finishing position or heart rates, indicating that the enzyme is not a good predictor of performance.
    Title: Circulating angiotensin converting enzyme in endurance horses: effect of exercise on blood levels and its value in predicting performance.
  2. This research investigated angiotensin-converting enzyme activity in the plasma of racehorses and demonstrated that its activity is increased in horses with higher degrees of hemorrhage and is a promising biomarker for pulmonary hemorrhage.
    Title: Association between circulating angiotensin-converting enzyme and exercise-induced pulmonary haemorrhage in Thoroughbred racehorses.
  3. These results show an increase in ACE activity up to fatigue and a return to baseline values at 30 min post exercise.
    Title: Effects of acute exercise on angiotensin I-converting enzyme (ACE) activity in horses.
  4. The aim of this study was to investigate the correlation between angiotensin-converting enzyme (ACE) activity in the equine endometrium and the degree of endometrial periglandular fibrosis.
    Title: Relationship between the degree of endometrial periglandular fibrosis and the presence of angiotensin-converting enzyme in the equine endometrium.
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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables peptidyl-dipeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of systemic arterial blood pressure IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of systemic arterial blood pressure by renin-angiotensin IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
angiotensin-converting enzyme
Names
angiotensin I converting enzyme (peptidyl-dipeptidase A) 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009154.3 Reference EquCab3.0 Primary Assembly

    Range
    15801253..15840520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001495589.6 → XP_001495639.4  angiotensin-converting enzyme isoform X2

    UniProtKB/TrEMBL
    A0A9R1SBF5, F6ZSR4, J7ILL4
    Related
    ENSECAP00000059847.1, ENSECAT00000091900.1
    Conserved Domains (1) summary
    pfam01401
    Location:650 → 1227
    Peptidase_M2; Angiotensin-converting enzyme

  2. XM_023652245.1 → XP_023508013.1  angiotensin-converting enzyme isoform X1

    UniProtKB/TrEMBL
    F6ZSR4, J7ILL4
    Related
    ENSECAP00000062361.1, ENSECAT00000081721.1
    Conserved Domains (1) summary
    pfam01401
    Location:47 → 629
    Peptidase_M2; Angiotensin-converting enzyme

  3. XM_023652246.1 → XP_023508014.1  angiotensin-converting enzyme isoform X3

    UniProtKB/TrEMBL
    A0A9L0RDC2
    Conserved Domains (1) summary
    pfam01401
    Location:497 → 1074
    Peptidase_M2; Angiotensin-converting enzyme

  4. XM_023652247.1 → XP_023508015.1  angiotensin-converting enzyme isoform X4

    UniProtKB/TrEMBL
    A0A3Q2LLZ7, A0A9L0RPY1
    Related
    ENSECAP00000064814.1, ENSECAT00000087664.1
    Conserved Domains (1) summary
    pfam01401
    Location:74 → 651
    Peptidase_M2; Angiotensin-converting enzyme
Nucleotide Protein
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