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SPOCK2 SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 [ Equus caballus (horse) ]

Gene ID: 100063582, updated on 17-Aug-2024

Summary

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Official Symbol
SPOCK2provided by VGNC
Official Full Name
SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2provided by VGNC
Primary source
VGNC:VGNC:23529
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See SPOCK2 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (60416094..60442742, complement)

Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111774198 Neighboring gene carbohydrate sulfotransferase 3 Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene DNA damage inducible transcript 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009144.3 Chromosome 1 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables collagen binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables extracellular matrix binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
testican-2
Names
SPARC/osteonectin, cwcv and kazal like domains proteoglycan 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009144.3 Reference EquCab3.0 Primary Assembly

    Range
    60416094..60442742 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005602453.3 → XP_005602510.1  testican-2 isoform X2

    See identical proteins and their annotated locations for XP_005602510.1

    UniProtKB/TrEMBL
    F6YRQ9
    Conserved Domains (4) summary
    smart00280
    Location:144 → 177
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:311 → 375
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:197 → 315
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:196 → 302
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region

  2. XM_005602452.3 → XP_005602509.1  testican-2 isoform X1

    See identical proteins and their annotated locations for XP_005602509.1

    UniProtKB/TrEMBL
    F6YRQ9
    Conserved Domains (4) summary
    smart00280
    Location:147 → 180
    KAZAL; Kazal type serine protease inhibitors
    cd00191
    Location:314 → 378
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    cd00252
    Location:200 → 318
    SPARC_EC; SPARC_EC; extracellular Ca2+ binding domain (containing 2 EF-hand motifs) of SPARC and related proteins (QR1, SC1/hevin, testican and tsc-36/FRP). SPARC (BM-40) is a multifunctional glycoprotein, a matricellular protein, that functions to regulate ...
    pfam10591
    Location:199 → 305
    SPARC_Ca_bdg; Secreted protein acidic and rich in cysteine Ca binding region
Nucleotide Protein
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