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LRP2 LDL receptor related protein 2 [ Equus caballus (horse) ]

Gene ID: 100062836, updated on 17-Aug-2024

Summary

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Official Symbol
LRP2provided by VGNC
Official Full Name
LDL receptor related protein 2provided by VGNC
Primary source
VGNC:VGNC:19761
See related
Ensembl:ENSECAG00000000435
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See LRP2 in Genome Data Viewer
Location:
chromosome: 18
Exon count:
79
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 18 NC_009161.3 (48816463..49014427, complement)

Chromosome 18 - NC_009161.3Genomic Context describing neighboring genes Neighboring gene ATP synthase subunit g, mitochondrial pseudogene Neighboring gene dehydrogenase/reductase 9 Neighboring gene uncharacterized LOC111768921 Neighboring gene uncharacterized LOC111768839

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009161.3 Chromosome 18 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables hormone binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in receptor-mediated endocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
low-density lipoprotein receptor-related protein 2
Names
low density lipoprotein receptor-related protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009161.3 Reference EquCab3.0 Primary Assembly

    Range
    48816463..49014427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005601570.3 → XP_005601627.2  low-density lipoprotein receptor-related protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2KXR4, F7B6L5
    Related
    ENSECAP00000029377.2, ENSECAT00000064961.2
    Conserved Domains (11) summary
    smart00192
    Location:2863 → 2895
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1501 → 1543
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4007 → 4047
    EGF_CA; Calcium-binding EGF-like domain
    COG3391
    Location:2092 → 2301
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00112
    Location:3719 → 3754
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:1065 → 1101
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:4197 → 4237
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl00104
    Location:2820 → 2854
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam07645
    Location:3152 → 3191
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:3132 → 3155
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1353 → 1388
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_023623091.1 → XP_023478859.1  low-density lipoprotein receptor-related protein 2 isoform X2

    UniProtKB/TrEMBL
    F6ZGI6
    Conserved Domains (11) summary
    smart00192
    Location:2863 → 2895
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:1501 → 1543
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:4007 → 4047
    EGF_CA; Calcium-binding EGF-like domain
    COG3391
    Location:2092 → 2301
    YncE; DNA-binding beta-propeller fold protein YncE [General function prediction only]
    cd00112
    Location:3719 → 3754
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:1065 → 1101
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:4197 → 4237
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    cl00104
    Location:2820 → 2854
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam12662
    Location:3132 → 3155
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:1353 → 1388
    FXa_inhibition; Coagulation Factor Xa inhibitory site
    cl00057
    Location:3147 → 3190
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
Nucleotide Protein
Heading Accession and Version

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