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HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 [ Equus caballus (horse) ]

Gene ID: 100059971, updated on 17-Aug-2024

Summary

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Official Symbol
HMGCS2provided by VGNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA synthase 2provided by VGNC
Primary source
VGNC:VGNC:18809
See related
Ensembl:ENSECAG00000000589
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See HMGCS2 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 5 NC_009148.3 (46448177..46468131)

Chromosome 5 - NC_009148.3Genomic Context describing neighboring genes Neighboring gene neuroblastoma breakpoint family member 6 Neighboring gene NBPF member 8 Neighboring gene uncharacterized LOC111773660 Neighboring gene phosphoglycerate dehydrogenase Neighboring gene zinc finger protein 697

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009148.3 Chromosome 5 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA synthase, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009148.3 Reference EquCab3.0 Primary Assembly

    Range
    46448177..46468131
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005610273.3 → XP_005610330.1  hydroxymethylglutaryl-CoA synthase, mitochondrial

    See identical proteins and their annotated locations for XP_005610330.1

    UniProtKB/TrEMBL
    A0A5F5PQJ1, F7CBP9
    Related
    ENSECAP00000000412.1, ENSECAT00000000529.4
    Conserved Domains (3) summary
    TIGR01833
    Location:50 → 506
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam01154
    Location:53 → 223
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
    pfam08540
    Location:224 → 506
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal

  2. XM_001501040.4 → XP_001501090.1  hydroxymethylglutaryl-CoA synthase, mitochondrial

    See identical proteins and their annotated locations for XP_001501090.1

    UniProtKB/TrEMBL
    A0A5F5PQJ1, F7CBP9
    Conserved Domains (3) summary
    TIGR01833
    Location:50 → 506
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam01154
    Location:53 → 223
    HMG_CoA_synt_N; Hydroxymethylglutaryl-coenzyme A synthase N terminal
    pfam08540
    Location:224 → 506
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
Nucleotide Protein
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