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DROSHA drosha ribonuclease III [ Equus caballus (horse) ]

Gene ID: 100054238, updated on 17-Aug-2024

Summary

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Official Symbol
DROSHAprovided by VGNC
Official Full Name
drosha ribonuclease IIIprovided by VGNC
Primary source
VGNC:VGNC:17318
See related
Ensembl:ENSECAG00000013578
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
RNASEN
Orthologs
human mouse all
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Genomic context

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See DROSHA in Genome Data Viewer
Location:
chromosome: 21
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 21 NC_009164.3 (33601777..33721170)

Chromosome 21 - NC_009164.3Genomic Context describing neighboring genes Neighboring gene PDZ domain containing 2 Neighboring gene uncharacterized LOC111769821 Neighboring gene chromosome 21 C5orf22 homolog Neighboring gene cadherin 6 Neighboring gene uncharacterized LOC111769824

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009164.3 Chromosome 21 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ribonuclease III activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in pre-miRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in primary miRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of microprocessor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ribonuclease 3
Names
ribonuclease type III, nuclear

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009164.3 Reference EquCab3.0 Primary Assembly

    Range
    33601777..33721170
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001500714.5 → XP_001500764.1  ribonuclease 3 isoform X1

    See identical proteins and their annotated locations for XP_001500764.1

    UniProtKB/TrEMBL
    A0A3Q2H5W9, F7CCV0
    Related
    ENSECAP00000012122.3, ENSECAT00000015113.4
    Conserved Domains (5) summary
    smart00358
    Location:1261 → 1332
    DSRM; Double-stranded RNA binding motif
    PRK00102
    Location:1105 → 1333
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:1122 → 1254
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam12871
    Location:219 → 277
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam15502
    Location:167 → 277
    MPLKIP; M-phase-specific PLK1-interacting protein

  2. XM_023625805.1 → XP_023481573.1  ribonuclease 3 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2H5W9
    Conserved Domains (3) summary
    cd00593
    Location:951 → 1071
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:218 → 278
    DUF1777; Protein of unknown function (DUF1777)
    cl25983
    Location:1097 → 1325
    Rnc; dsRNA-specific ribonuclease [Transcription]

  3. XM_023625807.1 → XP_023481575.1  ribonuclease 3 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2H5W9, F7C7Z7
    Related
    ENSECAP00000012144.3, ENSECAT00000015139.4
    Conserved Domains (3) summary
    cd00593
    Location:922 → 1042
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:230 → 361
    DUF1777; Protein of unknown function (DUF1777)
    cl25983
    Location:1068 → 1296
    Rnc; dsRNA-specific ribonuclease [Transcription]

  4. XM_023625806.1 → XP_023481574.1  ribonuclease 3 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2H5W9, A0A3Q2H7E3
    Related
    ENSECAP00000029769.2, ENSECAT00000056273.3
    Conserved Domains (4) summary
    cd00593
    Location:928 → 1048
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam17069
    Location:217 → 362
    RSRP; Arginine/Serine-Rich protein 1
    pfam08648
    Location:219 → 286
    DUF1777; Protein of unknown function (DUF1777)
    cl25983
    Location:1074 → 1302
    Rnc; dsRNA-specific ribonuclease [Transcription]

  5. XM_023625808.1 → XP_023481576.1  ribonuclease 3 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2H2A5, A0A3Q2H5W9
    Related
    ENSECAP00000027645.2, ENSECAT00000059846.3
    Conserved Domains (3) summary
    cd00593
    Location:891 → 1011
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:230 → 332
    DUF1777; Protein of unknown function (DUF1777)
    cl25983
    Location:1037 → 1265
    Rnc; dsRNA-specific ribonuclease [Transcription]

  6. XM_005604326.3 → XP_005604383.1  ribonuclease 3 isoform X1

    See identical proteins and their annotated locations for XP_005604383.1

    UniProtKB/TrEMBL
    A0A3Q2H5W9, F7CCV0
    Conserved Domains (5) summary
    smart00358
    Location:1261 → 1332
    DSRM; Double-stranded RNA binding motif
    PRK00102
    Location:1105 → 1333
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:1122 → 1254
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam12871
    Location:219 → 277
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam15502
    Location:167 → 277
    MPLKIP; M-phase-specific PLK1-interacting protein

  7. XM_023625809.1 → XP_023481577.1  ribonuclease 3 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2H5W9
    Conserved Domains (2) summary
    cd00593
    Location:959 → 1079
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam08648
    Location:218 → 278
    DUF1777; Protein of unknown function (DUF1777)

  8. XM_005604328.3 → XP_005604385.1  ribonuclease 3 isoform X1

    See identical proteins and their annotated locations for XP_005604385.1

    UniProtKB/TrEMBL
    A0A3Q2H5W9, F7CCV0
    Related
    ENSECAP00000029205.3, ENSECAT00000031172.3
    Conserved Domains (5) summary
    smart00358
    Location:1261 → 1332
    DSRM; Double-stranded RNA binding motif
    PRK00102
    Location:1105 → 1333
    rnc; ribonuclease III; Reviewed
    cd00593
    Location:1122 → 1254
    RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
    pfam12871
    Location:219 → 277
    PRP38_assoc; Pre-mRNA-splicing factor 38-associated hydrophilic C-term
    pfam15502
    Location:167 → 277
    MPLKIP; M-phase-specific PLK1-interacting protein
Nucleotide Protein
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