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PAH phenylalanine hydroxylase [ Equus caballus (horse) ]

Gene ID: 100053361, updated on 17-Aug-2024

Summary

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Official Symbol
PAHprovided by VGNC
Official Full Name
phenylalanine hydroxylaseprovided by VGNC
Primary source
VGNC:VGNC:21137
See related
Ensembl:ENSECAG00000019047
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See PAH in Genome Data Viewer
Location:
chromosome: 28
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 28 NC_009171.3 (27572190..27643783, complement)

Chromosome 28 - NC_009171.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111771124 Neighboring gene insulin like growth factor 1 Neighboring gene uncharacterized LOC111771043 Neighboring gene uncharacterized LOC106782695 Neighboring gene achaete-scute family bHLH transcription factor 1 Neighboring gene uncharacterized LOC106782720 Neighboring gene chromosome 28 C12orf42 homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009171.3 Chromosome 28 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables phenylalanine 4-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-phenylalanine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tyrosine biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
phenylalanine-4-hydroxylase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009171.3 Reference EquCab3.0 Primary Assembly

    Range
    27572190..27643783 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001497728.4 → XP_001497778.1  phenylalanine-4-hydroxylase

    See identical proteins and their annotated locations for XP_001497778.1

    UniProtKB/TrEMBL
    A0A3Q2HP12, A0A5F5PW17
    Related
    ENSECAP00000052447.2, ENSECAT00000071867.2
    Conserved Domains (3) summary
    TIGR01268
    Location:20 → 452
    Phe4hydrox_tetr; phenylalanine-4-hydroxylase, tetrameric form
    cd04931
    Location:21 → 110
    ACT_PAH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, phenylalanine hydroxylases (PAH)
    pfam00351
    Location:119 → 449
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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