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DIS3 DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease [ Equus caballus (horse) ]

Gene ID: 100051938, updated on 17-Aug-2024

Summary

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Official Symbol
DIS3provided by VGNC
Official Full Name
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonucleaseprovided by VGNC
Primary source
VGNC:VGNC:17194
See related
Ensembl:ENSECAG00000023994
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See DIS3 in Genome Data Viewer
Location:
chromosome: 17
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 17 NC_009160.3 (46167302..46191865, complement)

Chromosome 17 - NC_009160.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111768600 Neighboring gene mitotic spindle organizing protein 1 Neighboring gene BORA aurora kinase A activator Neighboring gene progesterone immunomodulatory binding factor 1 Neighboring gene 40S ribosomal protein S24 pseudogene Neighboring gene KLF transcription factor 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009160.3 Chromosome 17 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in rRNA catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of nuclear exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
exosome complex exonuclease RRP44
Names
DIS3 mitotic control homolog
exosome complex exonuclease RRP44-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009160.3 Reference EquCab3.0 Primary Assembly

    Range
    46167302..46191865 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023621680.1 → XP_023477448.1  exosome complex exonuclease RRP44 isoform X3

    UniProtKB/TrEMBL
    A0A9L0RXM9, A0A9L0SK87
    Related
    ENSECAP00000074624.1, ENSECAT00000132074.1
    Conserved Domains (2) summary
    COG0557
    Location:175 → 900
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:9 → 167
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  2. XM_001495217.6 → XP_001495267.1  exosome complex exonuclease RRP44 isoform X1

    See identical proteins and their annotated locations for XP_001495267.1

    UniProtKB/TrEMBL
    A0A9L0RXM9
    Related
    ENSECAP00000021549.3, ENSECAT00000025882.4
    Conserved Domains (3) summary
    cd09862
    Location:9 → 197
    PIN_Rrp44; PIN domain of yeast exosome subunit Rrp44 endoribonuclease and other eukaryotic homologs
    COG0557
    Location:205 → 930
    VacB; Exoribonuclease R [Transcription]
    pfam00773
    Location:467 → 795
    RNB; RNB domain

  3. XM_023621679.1 → XP_023477447.1  exosome complex exonuclease RRP44 isoform X2

    UniProtKB/TrEMBL
    A0A5F5PGD0
    Conserved Domains (2) summary
    COG0557
    Location:43 → 768
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:3 → 35
    PIN_SF; PIN (PilT N terminus) domain: Superfamily

  4. XM_005601268.3 → XP_005601325.1  exosome complex exonuclease RRP44 isoform X2

    See identical proteins and their annotated locations for XP_005601325.1

    UniProtKB/TrEMBL
    A0A5F5PGD0
    Conserved Domains (2) summary
    COG0557
    Location:43 → 768
    VacB; Exoribonuclease R [Transcription]
    cl14812
    Location:3 → 35
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein
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