FTL ferritin light chain [Equus caballus (horse)] - Gene

Summary

Gene symbol: FTL
Gene description: ferritin light chain
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: FT
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	10	NC_009153.3 (19192193..19193795)

Chromosome 10 - NC_009153.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009153.3 Chromosome 10 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A kinetic model is proposed in which the inhibition of the protein's activity is caused by bound iron(III) cations at the ferroxidase center, with the rate limiting step corresponding to an exchange or a displacement reaction between incoming iron(II) cations and bound Fe(III) cations.
Title: Ferritin exhibits Michaelis-Menten behavior with oxygen but not with iron during iron oxidation and core mineralization.
Transmission electron microscopy shows a clear selectivity of alkylated ferritin adsorption onto the PCL phase while wild ferritin predominantly adsorbs onto the PDTD phase.
Title: Selective adsorption of surface-modified ferritin on a phase-separated polymer blend.

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General gene information

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Markers

FTL (e-PCR), detects polymorphism
- UniSTS:504438

RH70278 (e-PCR)
- UniSTS:92393

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ferric iron binding	IEA Inferred from Electronic Annotation more info	PubMed
enables ferrous iron binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular iron ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in intracellular sequestering of iron ion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in iron ion transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ferritin light chain

Names: ferritin L subunit; ferritin, light polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001114540.1 → NP_001108012.1 ferritin light chain

See identical proteins and their annotated locations for NP_001108012.1

Status: PROVISIONAL

Source sequence(s)

AB175617

UniProtKB/Swiss-Prot

P02791, Q53VB4

Conserved Domains (1) summary

cd00904
Location:10 → 169

Ferritin; Ferritin iron storage proteins

RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

NC_009153.3 Reference EquCab3.0 Primary Assembly

Range

19192193..19193795

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_023649370.1 → XP_023505138.1 ferritin light chain isoform X1

UniProtKB/Swiss-Prot

P02791, Q53VB4

Conserved Domains (1) summary

cd00904
Location:10 → 169

Ferritin; Ferritin iron storage proteins