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TJP2 tight junction protein 2 [ Equus caballus (horse) ]

Gene ID: 100050442, updated on 17-Aug-2024

Summary

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Official Symbol
TJP2provided by VGNC
Official Full Name
tight junction protein 2provided by VGNC
Primary source
VGNC:VGNC:24119
See related
Ensembl:ENSECAG00000016742
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See TJP2 in Genome Data Viewer
Location:
chromosome: 23
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 23 NC_009166.3 (20801494..20917188, complement)

Chromosome 23 - NC_009166.3Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111770156 Neighboring gene endosomal transmembrane epsin interactor 1 Neighboring gene uncharacterized LOC111770157 Neighboring gene uncharacterized LOC111770158 Neighboring gene A-kinase anchor protein 17A pseudogene Neighboring gene frataxin Neighboring gene phosphatidylinositol-4-phosphate 5-kinase type 1 beta Neighboring gene PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009166.3 Chromosome 23 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cell adhesion molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell-cell adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell-cell junction organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in establishment of endothelial intestinal barrier IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of blood-brain barrier permeability IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein localization to cell-cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tight junction protein ZO-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009166.3 Reference EquCab3.0 Primary Assembly

    Range
    20801494..20917188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_023627247.1 → XP_023483015.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2KVV2
    Related
    ENSECAP00000034827.2, ENSECAT00000060447.2
    Conserved Domains (5) summary
    cd12027
    Location:565 → 627
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:661 → 840
    GuKc; Guanylate kinase homologues
    smart00228
    Location:271 → 352
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:135 → 284
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  2. XM_023627249.1 → XP_023483017.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2KVV2
    Conserved Domains (5) summary
    cd12027
    Location:565 → 627
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:661 → 840
    GuKc; Guanylate kinase homologues
    smart00228
    Location:271 → 352
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:135 → 284
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  3. XM_023627245.1 → XP_023483013.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2KVV2
    Related
    ENSECAP00000028407.2, ENSECAT00000041845.2
    Conserved Domains (5) summary
    cd12027
    Location:565 → 627
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:661 → 840
    GuKc; Guanylate kinase homologues
    smart00228
    Location:271 → 352
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:135 → 284
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  4. XM_023627251.1 → XP_023483019.1  tight junction protein ZO-2 isoform X6

    UniProtKB/TrEMBL
    A0A3Q2L7H5
    Conserved Domains (5) summary
    cd12027
    Location:588 → 650
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:684 → 863
    GuKc; Guanylate kinase homologues
    smart00228
    Location:294 → 375
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:158 → 307
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  5. XM_023627244.1 → XP_023483012.1  tight junction protein ZO-2 isoform X3

    UniProtKB/TrEMBL
    A0A3Q2L7H5
    Conserved Domains (5) summary
    cd12027
    Location:588 → 650
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:684 → 863
    GuKc; Guanylate kinase homologues
    smart00228
    Location:294 → 375
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:158 → 307
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  6. XM_023627242.1 → XP_023483010.1  tight junction protein ZO-2 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2L7H5
    Related
    ENSECAP00000034715.3, ENSECAT00000060527.3
    Conserved Domains (5) summary
    cd12027
    Location:588 → 650
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:684 → 863
    GuKc; Guanylate kinase homologues
    smart00228
    Location:294 → 375
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:32 → 117
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:158 → 307
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  7. XM_023627250.1 → XP_023483018.1  tight junction protein ZO-2 isoform X5

    UniProtKB/TrEMBL
    A0A3Q2GWH2, A0A3Q2KVV2
    Related
    ENSECAP00000024821.3, ENSECAT00000048784.3
    Conserved Domains (5) summary
    cd12027
    Location:592 → 654
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:688 → 867
    GuKc; Guanylate kinase homologues
    smart00228
    Location:298 → 379
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:162 → 311
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  8. XM_023627243.1 → XP_023483011.1  tight junction protein ZO-2 isoform X2

    UniProtKB/TrEMBL
    A0A3Q2KVV2, F7AZ87
    Related
    ENSECAP00000014912.4, ENSECAT00000018292.4
    Conserved Domains (5) summary
    cd12027
    Location:592 → 654
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:688 → 867
    GuKc; Guanylate kinase homologues
    smart00228
    Location:298 → 379
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:36 → 121
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:162 → 311
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

  9. XM_023627248.1 → XP_023483016.1  tight junction protein ZO-2 isoform X4

    UniProtKB/TrEMBL
    A0A3Q2KVV2
    Conserved Domains (5) summary
    cd12027
    Location:565 → 627
    SH3_ZO-2; Src homology 3 domain of the Tight junction protein, Zonula occludens protein 2
    smart00072
    Location:661 → 840
    GuKc; Guanylate kinase homologues
    smart00228
    Location:271 → 352
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:9 → 94
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl25887
    Location:135 → 284
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
Nucleotide Protein
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