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HECTD1 HECT domain E3 ubiquitin protein ligase 1 [ Equus caballus (horse) ]

Gene ID: 100050203, updated on 17-Aug-2024

Summary

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Official Symbol
HECTD1provided by VGNC
Official Full Name
HECT domain E3 ubiquitin protein ligase 1provided by VGNC
Primary source
VGNC:VGNC:18735
See related
Ensembl:ENSECAG00000023505
Gene type
protein coding
RefSeq status
MODEL
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Orthologs
human mouse all
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Genomic context

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See HECTD1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 1 NC_009144.3 (170535555..170623391, complement)

Chromosome 1 - NC_009144.3Genomic Context describing neighboring genes Neighboring gene striatin 3 Neighboring gene uncharacterized LOC111769672 Neighboring gene small nuclear ribonucleoprotein G pseudogene Neighboring gene adaptor related protein complex 4 subunit sigma 1 Neighboring gene small nuclear ribonucleoprotein F-like Neighboring gene 40S ribosomal protein S10 pseudogene Neighboring gene HEAT repeat containing 5A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009144.3 Chromosome 1 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein K63-linked ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD1
Names
HECT domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009144.3 Reference EquCab3.0 Primary Assembly

    Range
    170535555..170623391 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005603422.3 → XP_005603479.2  E3 ubiquitin-protein ligase HECTD1 isoform X5

    UniProtKB/TrEMBL
    F6YMU8
    Related
    ENSECAP00000021258.3, ENSECAT00000025553.3
    Conserved Domains (5) summary
    cd00078
    Location:1852 → 2329
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1302
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal

  2. XM_005603419.3 → XP_005603476.2  E3 ubiquitin-protein ligase HECTD1 isoform X3

    UniProtKB/TrEMBL
    F6YMU8
    Related
    ENSECAP00000063582.1, ENSECAT00000122516.1
    Conserved Domains (5) summary
    cd00078
    Location:2084 → 2561
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1321
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal

  3. XM_014734146.2 → XP_014589632.2  E3 ubiquitin-protein ligase HECTD1 isoform X2

    UniProtKB/TrEMBL
    F6YMU8
    Conserved Domains (5) summary
    cd00078
    Location:2129 → 2606
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal

  4. XM_014734147.2 → XP_014589633.2  E3 ubiquitin-protein ligase HECTD1 isoform X4

    UniProtKB/TrEMBL
    F6YMU8, F6YN41
    Related
    ENSECAP00000021245.2, ENSECAT00000025538.4
    Conserved Domains (5) summary
    cd00078
    Location:2070 → 2547
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal

  5. XM_001489863.6 → XP_001489913.3  E3 ubiquitin-protein ligase HECTD1 isoform X1

    UniProtKB/TrEMBL
    A0A3Q2L991, F6YMU8
    Related
    ENSECAP00000035860.1, ENSECAT00000058185.2
    Conserved Domains (5) summary
    cd00078
    Location:2131 → 2608
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    cd00204
    Location:369 → 479
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:396 → 426
    ANK; ANK repeat [structural motif]
    pfam06701
    Location:1277 → 1335
    MIB_HERC2; Mib_herc2
    pfam07738
    Location:1107 → 1240
    Sad1_UNC; Sad1 / UNC-like C-terminal
Nucleotide Protein
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