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Gvin2 GTPase, very large interferon inducible, family member 2 [ Mus musculus (house mouse) ]

Gene ID: 100042856, updated on 2-Nov-2024

Summary

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Official Symbol
Gvin2provided by MGI
Official Full Name
GTPase, very large interferon inducible, family member 2provided by MGI
Primary source
MGI:MGI:3782245
See related
Ensembl:ENSMUSG00000078606 AllianceGenome:MGI:3782245
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4070; VLIG-1
Summary
Orthologous to human GVINP1 (GTPase, very large interferon inducible pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in spleen adult (RPKM 1.7), mammary gland adult (RPKM 1.5) and 21 other tissues See more
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Genomic context

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See Gvin2 in Genome Data Viewer
Location:
7 E3; 7 55.98 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (105544325..105603174, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (105895118..105953967, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene GTPase, very large interferon inducible, pseudogene 1 Neighboring gene predicted gene 15645 Neighboring gene GTPase, very large interferon inducible, pseudogene 2 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113101005-113101306 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113102439-113102740 Neighboring gene STARR-positive B cell enhancer mm9_chr7:113198665-113198966 Neighboring gene GTPase, very large interferon inducible, pseudogene 3 Neighboring gene ornithine decarboxylase, structural 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry. Dai J, et al. J Proteome Res, 2007 Jan. PMID 17203969
  2. A giant GTPase, very large inducible GTPase-1, is inducible by IFNs. Klamp T, et al. J Immunol, 2003 Aug 1. PMID 12874213
  3. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article
  4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
  5. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
interferon-induced very large GTPase 1
Names
very large inducible GTPase-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243039.1 → NP_001229968.1  interferon-induced very large GTPase 1

    See identical proteins and their annotated locations for NP_001229968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AY167972, BY199517, BY577205, BY579139
    Consensus CDS
    CCDS57577.1
    UniProtKB/Swiss-Prot
    Q3U3F2, Q80SU7, Q8BL18, Q8CBA9
    Related
    ENSMUSP00000135898.2, ENSMUST00000176467.8
    Conserved Domains (3) summary
    PRK00247
    Location:72 → 139
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    TIGR02168
    Location:1206 → 1432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl38936
    Location:1485 → 1562
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  2. NM_001243040.1 → NP_001229969.1  interferon-induced very large GTPase 1

    See identical proteins and their annotated locations for NP_001229969.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two internal exons in the 5' UTR and encodes the same protein, compared to variant 1.
    Source sequence(s)
    AY167972, AY167973, BY199517, BY577205, BY579139
    Consensus CDS
    CCDS57577.1
    UniProtKB/Swiss-Prot
    Q3U3F2, Q80SU7, Q8BL18, Q8CBA9
    Related
    ENSMUSP00000102377.3, ENSMUST00000106766.9
    Conserved Domains (3) summary
    PRK00247
    Location:72 → 139
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    TIGR02168
    Location:1206 → 1432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl38936
    Location:1485 → 1562
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    105544325..105603174 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321896.1 → XP_017177385.1  interferon-induced very large GTPase 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3U3F2, Q80SU7, Q8BL18, Q8CBA9
    Conserved Domains (3) summary
    PRK00247
    Location:72 → 139
    PRK00247; putative inner membrane protein translocase component YidC; Validated
    TIGR02168
    Location:1206 → 1432
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    cl38936
    Location:1485 → 1562
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80SU7.1 GenPept UniProtKB/Swiss-Prot:Q80SU7

Gene LinkOut

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