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Mndal myeloid nuclear differentiation antigen like [ Mus musculus (house mouse) ]

Gene ID: 100040462, updated on 2-Nov-2024

Summary

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Official Symbol
Mndalprovided by MGI
Official Full Name
myeloid nuclear differentiation antigen likeprovided by MGI
Primary source
MGI:MGI:3780953
See related
Ensembl:ENSMUSG00000090272 AllianceGenome:MGI:3780953
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm2785; Ifi212
Summary
Predicted to enable double-stranded DNA binding activity and identical protein binding activity. Involved in negative regulation of cell growth. Located in nucleus. Is expressed in central nervous system and retina. Orthologous to human IFI16 (interferon gamma inducible protein 16). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Broad expression in bladder adult (RPKM 3.3), spleen adult (RPKM 2.7) and 18 other tissues See more
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Genomic context

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See Mndal in Genome Data Viewer
Location:
1 H3; 1 80.71 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (173684786..173708038, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (173857215..173880382, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene interferon activated gene 204 Neighboring gene interferon activated gene 203, pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr1:175731887-175732188 Neighboring gene STARR-positive B cell enhancer mm9_chr1:175783692-175783993 Neighboring gene STARR-seq mESC enhancer starr_03084 Neighboring gene STARR-positive B cell enhancer ABC_E801 Neighboring gene predicted gene, 21031 Neighboring gene STARR-positive B cell enhancer ABC_E11108 Neighboring gene interferon activated gene 211

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility. Zhang K, et al. Blood, 2009 Oct 1. PMID 19654412, Free PMC Article
  2. The mammalian PYHIN gene family: phylogeny, evolution and expression. Cridland JA, et al. BMC Evol Biol, 2012 Aug 7. PMID 22871040, Free PMC Article
  3. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. Brunette RL, et al. J Exp Med, 2012 Oct 22. PMID 23045604, Free PMC Article
  4. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mndal acts as a tumor suppressor and displays haploinsufficiency
    Title: Mndal, a new interferon-inducible family member, is highly polymorphic, suppresses cell growth, and may modify plasmacytoma susceptibility.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in activation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in activation of innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interferon-beta IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
involved_in monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of AIM2 inflammasome complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA binding ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cysteine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression, epigenetic ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of viral genome replication ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
colocalizes_with cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
myeloid cell nuclear differentiation antigen-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170853.1 → NP_001164324.1  myeloid cell nuclear differentiation antigen-like protein isoform 1

    See identical proteins and their annotated locations for NP_001164324.1

    Status: VALIDATED

    Source sequence(s)
    AK136391, FJ594740
    Consensus CDS
    CCDS48452.1
    UniProtKB/Swiss-Prot
    D0QMC3, D0QMC4
    UniProtKB/TrEMBL
    A0A1Z3MHX2
    Related
    ENSMUSP00000140610.2, ENSMUST00000188804.7
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:311 → 479
    HIN; HIN-200/IF120x domain

  2. NM_001374640.1 → NP_001361569.1  myeloid cell nuclear differentiation antigen-like protein isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC170584
    Consensus CDS
    CCDS87927.1
    UniProtKB/TrEMBL
    A0A087WRA4
    Related
    ENSMUSP00000140539.2, ENSMUST00000186442.7
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:258 → 426
    HIN; HIN-200/IF120x domain

  3. NM_001400321.1 → NP_001387250.1  myeloid cell nuclear differentiation antigen-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC170584
    UniProtKB/Swiss-Prot
    D0QMC3, D0QMC4

  4. NM_001400322.1 → NP_001387251.1  myeloid cell nuclear differentiation antigen-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC170584
    UniProtKB/Swiss-Prot
    D0QMC3, D0QMC4

  5. NM_001400323.1 → NP_001387252.1  myeloid cell nuclear differentiation antigen-like protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC170584

RNA

  1. NR_174474.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170584

  2. NR_174475.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC170584

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    173684786..173708038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165678.1 → XP_036021571.1  myeloid cell nuclear differentiation antigen-like protein isoform X1

    UniProtKB/Swiss-Prot
    D0QMC3, D0QMC4
    UniProtKB/TrEMBL
    A0A1Z3MHX2
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:311 → 479
    HIN; HIN-200/IF120x domain

  2. XM_036165719.1 → XP_036021612.1  myeloid cell nuclear differentiation antigen-like protein isoform X1

    UniProtKB/Swiss-Prot
    D0QMC3, D0QMC4
    UniProtKB/TrEMBL
    A0A1Z3MHX2
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:311 → 479
    HIN; HIN-200/IF120x domain

  3. XM_036166134.1 → XP_036022027.1  myeloid cell nuclear differentiation antigen-like protein isoform X4

    Conserved Domains (1) summary
    pfam02760
    Location:188 → 356
    HIN; HIN-200/IF120x domain

  4. XM_036152286.1 → XP_036008179.1  myeloid cell nuclear differentiation antigen-like protein isoform X5

    Conserved Domains (1) summary
    pfam02760
    Location:132 → 300
    HIN; HIN-200/IF120x domain

  5. XM_036166009.1 → XP_036021902.1  myeloid cell nuclear differentiation antigen-like protein isoform X3

    UniProtKB/TrEMBL
    A0A087WRA4
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:258 → 426
    HIN; HIN-200/IF120x domain

  6. XM_036165861.1 → XP_036021754.1  myeloid cell nuclear differentiation antigen-like protein isoform X2

    UniProtKB/TrEMBL
    A0A1Z3MHX2
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:311 → 479
    HIN; HIN-200/IF120x domain

  7. XM_036152235.1 → XP_036008128.1  myeloid cell nuclear differentiation antigen-like protein isoform X4

    Conserved Domains (1) summary
    pfam02760
    Location:188 → 356
    HIN; HIN-200/IF120x domain

  8. XM_036165636.1 → XP_036021529.1  myeloid cell nuclear differentiation antigen-like protein isoform X1

    UniProtKB/Swiss-Prot
    D0QMC3, D0QMC4
    UniProtKB/TrEMBL
    A0A1Z3MHX2
    Conserved Domains (2) summary
    cd08305
    Location:9 → 82
    Pyrin; a protein-protein interaction domain
    pfam02760
    Location:311 → 479
    HIN; HIN-200/IF120x domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D0QMC3.1 GenPept UniProtKB/Swiss-Prot:D0QMC3

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