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Sirpb1c signal-regulatory protein beta 1C [ Mus musculus (house mouse) ]

Gene ID: 100038947, updated on 2-Nov-2024

Summary

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Official Symbol
Sirpb1cprovided by MGI
Official Full Name
signal-regulatory protein beta 1Cprovided by MGI
Primary source
MGI:MGI:3807521
See related
Ensembl:ENSMUSG00000074677 AllianceGenome:MGI:3807521
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to be involved in positive regulation of T cell activation and positive regulation of phagocytosis. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to several human genes including SIRPB1 (signal regulatory protein beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis adult (RPKM 2.4), lung adult (RPKM 2.0) and 7 other tissues See more
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Genomic context

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See Sirpb1c in Genome Data Viewer
Location:
3; 3 A1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (15849311..15902694, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (15795147..15848530, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene signal-regulatory protein beta 1B Neighboring gene zinc finger protein 947 pseudogene Neighboring gene predicted gene, 54192 Neighboring gene eukaryotic translation initiation factor 3, subunit M pseudogene Neighboring gene STARR-seq mESC enhancer starr_07028 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoribosylaminoimidazole, succinocarboxamide synthetase pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Positive regulation of phagocytosis by SIRPbeta and its signaling mechanism in macrophages. Hayashi A, et al. J Biol Chem, 2004 Jul 9. PMID 15123631
  2. Signal regulatory protein molecules are differentially expressed by CD8- dendritic cells. Lahoud MH, et al. J Immunol, 2006 Jul 1. PMID 16785533
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
signal-regulatory protein beta 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173459.2 → NP_001166930.1  signal-regulatory protein beta 1-like precursor

    See identical proteins and their annotated locations for NP_001166930.1

    Status: VALIDATED

    Source sequence(s)
    AK155731, BY551146, DQ055453
    Consensus CDS
    CCDS50868.1
    UniProtKB/TrEMBL
    Q1AN90, Q76CT6
    Related
    ENSMUSP00000061216.5, ENSMUST00000050623.11
    Conserved Domains (4) summary
    cd00098
    Location:247 → 341
    IgC; Immunoglobulin Constant domain
    smart00410
    Location:42 → 119
    IG_like; Immunoglobulin like
    pfam07686
    Location:45 → 142
    V-set; Immunoglobulin V-set domain
    cl11960
    Location:141 → 252
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    15849311..15902694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535371.1 → XP_006535434.1  signal-regulatory protein beta 1-like isoform X1

    UniProtKB/TrEMBL
    Q76CT6
    Related
    ENSMUSP00000103986.2, ENSMUST00000108349.2
    Conserved Domains (3) summary
    cd05772
    Location:143 → 246
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:248 → 350
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:30 → 140
    Ig; Immunoglobulin domain

  2. XM_006535373.5 → XP_006535436.1  signal-regulatory protein beta 1-like isoform X2

    See identical proteins and their annotated locations for XP_006535436.1

    UniProtKB/TrEMBL
    F6UP26
    Conserved Domains (2) summary
    cd05772
    Location:2 → 99
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:101 → 203
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3

  3. XM_006535372.5 → XP_006535435.1  signal-regulatory protein beta 1-like isoform X2

    See identical proteins and their annotated locations for XP_006535435.1

    UniProtKB/TrEMBL
    F6UP26
    Conserved Domains (2) summary
    cd05772
    Location:2 → 99
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:101 → 203
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
Nucleotide Protein Strain
Heading Accession and Version

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