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Pira12 paired-Ig-like receptor A12 [ Mus musculus (house mouse) ]

Gene ID: 100038909, updated on 2-Nov-2024

Summary

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Official Symbol
Pira12provided by MGI
Official Full Name
paired-Ig-like receptor A12provided by MGI
Primary source
MGI:MGI:3709645
See related
Ensembl:ENSMUSG00000074417 AllianceGenome:MGI:3709645
Gene type
protein coding
RefSeq status
INFERRED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm14548
Summary
Predicted to enable several functions, including IgM binding activity; coreceptor activity; and inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be part of Fc-epsilon receptor I complex. Predicted to be active in plasma membrane. Orthologous to several human genes including LILRA4 (leukocyte immunoglobulin like receptor A4); LILRA6 (leukocyte immunoglobulin like receptor A6); and LILRB3 (leukocyte immunoglobulin like receptor B3). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in spleen adult (RPKM 29.6), mammary gland adult (RPKM 15.0) and 13 other tissues See more
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Genomic context

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See Pira12 in Genome Data Viewer
Location:
7 A1; 7 2.24 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (3887200..3901158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (3884201..3898159, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr7:3796869-3797170 Neighboring gene paired-Ig-like receptor A2 Neighboring gene predicted pseudogene 10693 Neighboring gene leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6 Neighboring gene RIKEN cDNA 1700095K22 gene Neighboring gene STARR-seq mESC enhancer starr_17915

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PIRs mediate innate myeloid cell memory to nonself MHC molecules. Dai H, et al. Science, 2020 Jun 5. PMID 32381589, Free PMC Article
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables IgM binding ISO
Inferred from Sequence Orthology
more info
  
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
  
enables inhibitory MHC class I receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cytokine-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response-regulating signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Fc-epsilon receptor I complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
paired-Ig-like receptor A12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166672.2 → NP_001160144.1  paired-Ig-like receptor A12 precursor 1 precursor

    Status: INFERRED

    Source sequence(s)
    AC161409
    UniProtKB/TrEMBL
    E9Q1Z6, Q3ZB55
    Related
    ENSMUSP00000070073.8, ENSMUST00000070639.8
    Conserved Domains (2) summary
    smart00410
    Location:529 → 617
    IG_like; Immunoglobulin like
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

  2. NM_001384210.1 → NP_001371139.1  paired-Ig-like receptor A12 precursor 2 precursor

    Status: INFERRED

    Source sequence(s)
    AC161409
    UniProtKB/TrEMBL
    O70434
    Conserved Domains (3) summary
    cd00096
    Location:124 → 128
    Ig; Ig strand A [structural motif]
    cd16843
    Location:225 → 314
    IgC2_D1_D2_LILR_KIR_like; Immunoglobulin (Ig)-like domain found in Leukocyte Ig-like receptors, Natural killer inhibitory receptors (KIRs) and similar domains; member of Immunoglobulin Constant-2 set of IgSF domains
    cl11960
    Location:123 → 219
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    3887200..3901158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006539428.4 → XP_006539491.1  paired-Ig-like receptor A12 isoform X1

    UniProtKB/TrEMBL
    O70434
    Conserved Domains (1) summary
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain

  2. XM_006539430.2 → XP_006539493.1  paired-Ig-like receptor A12 isoform X3

    Conserved Domains (1) summary
    cl11960
    Location:27 → 118
    Ig; Immunoglobulin domain

  3. XM_006539429.5 → XP_006539492.1  paired-Ig-like receptor A12 isoform X2

    UniProtKB/TrEMBL
    O55002
    Conserved Domains (1) summary
    cl11960
    Location:225 → 315
    Ig; Immunoglobulin domain
Nucleotide Protein
Heading Accession and Version

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