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kng1 kininogen 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100038066, updated on 4-Nov-2024

Summary

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Official Symbol
kng1provided by Xenbase
Official Full Name
kininogen 1provided by Xenbase
Primary source
Xenbase:XB-GENE-479795
See related
Ensembl:ENSXETG00000040291 AllianceGenome:Xenbase:XB-GENE-479795
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
bdk; kng; kininogen; kininogen1; kininogen-1
Summary
Predicted to enable cysteine-type endopeptidase inhibitor activity. Human ortholog(s) of this gene implicated in hereditary angioedema and high molecular weight kininogen deficiency. Orthologous to human KNG1 (kininogen 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See kng1 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 5 NC_030681.2 (105937027..105960107, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 5 NC_030681.1 (97971065..97993722)

Chromosome 5 - NC_030681.2Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 4A2 Neighboring gene small nucleolar RNA SNORD2 Neighboring gene small nucleolar RNA SNORD2 Neighboring gene histidine rich glycoprotein Neighboring gene fetuin B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kininogen-1
Names
fitzgerald factor

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030681.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    105937027..105960107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_004914366.4 → XP_004914423.2  kininogen-1

    UniProtKB/TrEMBL
    A0A6I8RDQ6, A0A6I8SU67
    Conserved Domains (3) summary
    smart00043
    Location:141 → 250
    CY; Cystatin-like domain
    pfam00031
    Location:22 → 114
    Cystatin; Cystatin domain
    cl09238
    Location:256 → 347
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.

  2. XM_002937827.4 → XP_002937873.3  kininogen-1

    UniProtKB/TrEMBL
    A0A6I8RDQ6, A0A6I8SU67
    Related
    ENSXETP00000079038.2, ENSXETT00000079370.2
    Conserved Domains (3) summary
    smart00043
    Location:141 → 250
    CY; Cystatin-like domain
    pfam00031
    Location:22 → 114
    Cystatin; Cystatin domain
    cl09238
    Location:256 → 347
    CY; Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains.
Nucleotide Protein Strain
Heading Accession and Version

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