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PRKCA protein kinase C alpha [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100037720, updated on 10-Oct-2024

Summary

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Gene symbol
PRKCA
Gene description
protein kinase C alpha
See related
Ensembl:ENSOCUG00000007362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See PRKCA in Genome Data Viewer
Location:
chromosome: 19
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 19 NC_067392.1 (48125986..48559757, complement)

Chromosome 19 - NC_067392.1Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 4 Neighboring gene calcium voltage-gated channel auxiliary subunit gamma 5 Neighboring gene centrosomal protein 112 Neighboring gene apolipoprotein H

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067392.1 Chromosome 19 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protein kinase C and Ca(2+) -calmodulin-dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain-increased late sodium current in rabbit ventricular myocytes. Wu Y, et al. Exp Physiol, 2015 Apr 1. PMID 25641541
  2. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells. Haughian JM, et al. J Cell Physiol, 2009 Jul. PMID 19235902
  3. Protein kinase C-epsilon is necessary for erythropoietin's up-regulation of c-myc and for factor-dependent DNA synthesis. Evidence for discrete signals for growth and differentiation. Li Y, et al. J Biol Chem, 1996 Oct 25. PMID 8900191
  4. Tissue-specific expression of three distinct types of rabbit protein kinase C. Ohno S, et al. Nature, 1987 Jan 8-14. PMID 3808073
  5. Small Molecular-Sized Artesunate Attenuates Ocular Neovascularization via VEGFR2, PKCα, and PDGFR Targets. Zong Y, et al. Sci Rep, 2016 Aug 2. PMID 27480521, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High PKC alpha expression is associated with retinal neovascularization.
    Title: Small Molecular-Sized Artesunate Attenuates Ocular Neovascularization via VEGFR2, PKCα, and PDGFR Targets.
  2. We conclude that ouabain, even at low concentrations (0.5-8.0 mum), can increase INaL and reverse INCX , and these effects may contribute to the effect of the glycoside to increase Ca(2+) transients and contractility.
    Title: Protein kinase C and Ca(2+) -calmodulin-dependent protein kinase II mediate the enlarged reverse INCX induced by ouabain-increased late sodium current in rabbit ventricular myocytes.
  3. These results suggest a complex antagonistic interplay between G(q)-activated PKC and Gbetagamma in regulation of L-VDCC, in which multiple cytosolic segments of alpha(1C) are involved.
    Title: Modulation of distinct isoforms of L-type calcium channels by G(q)-coupled receptors in Xenopus oocytes: antagonistic effects of Gβγ and protein kinase C.
  4. Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
    Title: Protein kinase C alpha (PKCalpha) regulates growth and invasion of endometrial cancer cells.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein kinase C alpha type
Names
PKC-A
PKC-alpha
NP_001095194.1
XP_051680361.1
XP_051680362.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101724.1 → NP_001095194.1  protein kinase C alpha type

    See identical proteins and their annotated locations for NP_001095194.1

    Status: PROVISIONAL

    Source sequence(s)
    X04796
    UniProtKB/Swiss-Prot
    P10102
    UniProtKB/TrEMBL
    A0A5F9DNQ2
    Related
    ENSOCUP00000047258.1, ENSOCUT00000040139.1
    Conserved Domains (4) summary
    cd04026
    Location:159 → 289
    C2_PKC_alpha_gamma; C2 domain in Protein Kinase C (PKC) alpha and gamma
    smart00220
    Location:339 → 597
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd05615
    Location:328 → 668
    STKc_cPKC_alpha; Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha
    pfam00130
    Location:37 → 89
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067392.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    48125986..48559757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051824401.1 → XP_051680361.1  protein kinase C alpha type isoform X1

  2. XM_051824402.1 → XP_051680362.1  protein kinase C alpha type isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P10102.3 GenPept UniProtKB/Swiss-Prot:P10102

Gene LinkOut

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