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mfsd4b major facilitator superfamily domain containing 4B [ Danio rerio (zebrafish) ]

Gene ID: 100037368, updated on 2-Nov-2024

Summary

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Official Symbol
mfsd4bprovided by ZNC
Official Full Name
major facilitator superfamily domain containing 4Bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-070410-26
See related
Ensembl:ENSDARG00000079571 AllianceGenome:ZFIN:ZDB-GENE-070410-26
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
naglt1; mfsd4b1; zgc:162161
Summary
Predicted to enable D-glucose transmembrane transporter activity. Predicted to act upstream of or within sodium ion transport and transmembrane transport. Predicted to be located in apical plasma membrane. Orthologous to human MFSD4B (major facilitator superfamily domain containing 4B). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human all
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Genomic context

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See mfsd4b in Genome Data Viewer
Location:
chromosome: 20
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (3339248..3345526)
105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (3321747..3328025)

Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene small nucleolar RNA U3 Neighboring gene REV3 like, DNA directed polymerase zeta catalytic subunit Neighboring gene TRAF3 interacting protein 2a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characteristics of 29 novel atypical solute carriers of major facilitator superfamily type: evolutionary conservation, predicted structure and neuronal co-expression. Perland E, et al. Open Biol, 2017 Sep. PMID 28878041, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables D-glucose transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
sodium-dependent glucose transporter 1
Names
major facilitator superfamily domain-containing protein 4B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001089520.1 → NP_001082989.1  sodium-dependent glucose transporter 1

    See identical proteins and their annotated locations for NP_001082989.1

    Status: PROVISIONAL

    Source sequence(s)
    BC134911
    UniProtKB/Swiss-Prot
    A4QN56
    Related
    ENSDARP00000101496.2, ENSDART00000108955.3
    Conserved Domains (2) summary
    cd06174
    Location:81 → 487
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam07690
    Location:79 → 447
    MFS_1; Major Facilitator Superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007131.7 Reference GRCz11 Primary Assembly

    Range
    3339248..3345526
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A4QN56.1 GenPept UniProtKB/Swiss-Prot:A4QN56

Gene LinkOut

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