sgpl1 sphingosine-1-phosphate lyase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sgpl1provided by ZNC
Official Full Name: sphingosine-1-phosphate lyase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-070410-24
See related: Ensembl:ENSDARG00000061375 AllianceGenome:ZFIN:ZDB-GENE-070410-24
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:162153
Summary: Predicted to enable sphinganine-1-phosphate aldolase activity. Predicted to be involved in sphingolipid catabolic process. Predicted to act upstream of or within carboxylic acid metabolic process. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk syncytial layer. Human ortholog(s) of this gene implicated in nephrotic syndrome type 14. Orthologous to human SGPL1 (sphingosine-1-phosphate lyase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (25727894..25750910, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (25597444..25620460, complement)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables carbon-carbon lyase activity	IEA Inferred from Electronic Annotation more info
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables sphinganine-1-phosphate aldolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables sphinganine-1-phosphate aldolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sphingolipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sphingosine-1-phosphate lyase 1

Names: spl

NP_001082938.1

EC 4.1.2.27

XP_005156777.1

EC 4.1.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001089469.1 → NP_001082938.1 sphingosine-1-phosphate lyase 1

See identical proteins and their annotated locations for NP_001082938.1

Status: PROVISIONAL

Source sequence(s)

BC139528

UniProtKB/TrEMBL

A0A8M1NEA0, A4QNU7

Related

ENSDARP00000098071.2, ENSDART00000111567.4

Conserved Domains (1) summary

cd06450
Location:141 → 502

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007124.7 Reference GRCz11 Primary Assembly

Range

25727894..25750910 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005156720.5 → XP_005156777.1 sphingosine-1-phosphate lyase 1 isoform X1

UniProtKB/TrEMBL

A0A2R8Q3N8, A0A8M2B2S5

Related

ENSDARP00000147330.1, ENSDART00000189333.1

Conserved Domains (1) summary

cd06450
Location:143 → 504

DOPA_deC_like; DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and ...