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uhrf2.L ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100037238, updated on 4-Nov-2024

Summary

Official Symbol
uhrf2.L
Official Full Name
ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase L homeolog
Primary source
Xenbase:XB-GENE-6054048
Locus tag
XELAEV_18006817mg
See related
EnsemblRapid:ENSXLAG00005005515 AllianceGenome:Xenbase:XB-GENE-6054048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
nirf; urf2; uhrf2
Summary
Predicted to enable several functions, including histone binding activity; metal ion binding activity; and ubiquitin protein ligase activity. Predicted to act upstream of or within protein ubiquitination. Predicted to be located in nucleus. Orthologous to human UHRF2 (ubiquitin like with PHD and ring finger domains 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See uhrf2.L in Genome Data Viewer
Location:
chromosome: 1L
Exon count:
16
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 1L NC_054371.1 (137148818..137240669, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 1L NC_030724.1 (124805003..124896913, complement)

Chromosome 1L - NC_054371.1Genomic Context describing neighboring genes Neighboring gene lysine (K)-specific demethylase 4C L homeolog Neighboring gene glycine dehydrogenase (decarboxylating), mitochondrial-like Neighboring gene bromodomain containing 10 L homeolog Neighboring gene frataxin L homeolog

Genomic regions, transcripts, and products

General gene information

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables histone binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
ubiquitin-like with PHD and ring finger domains 2
Names
Np95-like ring finger protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097915.1NP_001091384.1  ubiquitin-like with PHD and ring finger domains 2

    See identical proteins and their annotated locations for NP_001091384.1

    Status: PROVISIONAL

    Source sequence(s)
    BC128673
    UniProtKB/TrEMBL
    A0A974DZC0, A1A5J0
    Related
    ENSXLAP00005016304.1, ENSXLAT00005016598.1
    Conserved Domains (7) summary
    cd01797
    Location:174
    NIRF_N; amino-terminal ubiquitin-like domain of Np95 and NIRF
    smart00213
    Location:374
    UBQ; Ubiquitin homologues
    cd00162
    Location:775818
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cd15617
    Location:342388
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    pfam02182
    Location:442609
    SAD_SRA; SAD/SRA domain
    pfam12148
    Location:124308
    TTD; Tandem tudor domain within UHRF1
    pfam16228
    Location:643740
    DUF4887; Domain of unknown function (DUF4887)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054371.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    137148818..137240669 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041567060.1XP_041422994.1  ubiquitin-like with PHD and ring finger domains 2 isoform X1

    UniProtKB/TrEMBL
    A0A8J1L344
    Related
    ENSXLAP00005016295.1, ENSXLAT00005016587.1
    Conserved Domains (4) summary
    cd15617
    Location:342388
    PHD_UHRF2; PHD finger found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cd17123
    Location:174
    Ubl_UHRF2; ubiquitin-like (Ubl) domain found in ubiquitin-like PHD and RING finger domain-containing protein 2 (UHRF2)
    cl02620
    Location:439611
    SAD_SRA; SAD/SRA domain
    cl17238
    Location:765786
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain