ddx1.L DEAD/H-box helicase 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: ddx1.L
Official Full Name: DEAD/H-box helicase 1 L homeolog
Primary source: Xenbase:XB-GENE-969102
Locus tag: XELAEV_18028071mg
See related: EnsemblRapid:ENSXLAG00005031323 AllianceGenome:Xenbase:XB-GENE-969102
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ddx1
Summary: Predicted to enable several functions, including helicase activity; poly(A) binding activity; and transcription coregulator activity. Predicted to act upstream of or within DNA duplex unwinding; double-strand break repair; and tRNA splicing, via endonucleolytic cleavage and ligation. Predicted to be located in cytosol; mitochondrion; and nucleus. Predicted to be part of tRNA-splicing ligase complex. Orthologous to human DDX1 (DEAD-box helicase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5L

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5L	NC_054379.1 (151905720..151931739)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5L	NC_030732.1 (140833333..140859353)

Chromosome 5L - NC_054379.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA/RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISS Inferred from Sequence or Structural Similarity more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables nuclease activity	ISS Inferred from Sequence or Structural Similarity more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables poly(A) binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coregulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA duplex unwinding	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within double-strand break repair	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tRNA splicing, via endonucleolytic cleavage and ligation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
part_of tRNA-splicing ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ATP-dependent RNA helicase DDX1

Names: DEAD (Asp-Glu-Ala-Asp) box helicase 1; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1

NP_001091352.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097883.1 → NP_001091352.1 ATP-dependent RNA helicase DDX1

See identical proteins and their annotated locations for NP_001091352.1

Status: PROVISIONAL

Source sequence(s)

BC129617

UniProtKB/Swiss-Prot

A2VD92

UniProtKB/TrEMBL

A0A974CWJ6

Related

ENSXLAP00005094394.1, ENSXLAT00005096095.1

Conserved Domains (4) summary

COG0513
Location:284 → 624

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

pfam00271
Location:493 → 609

Helicase_C; Helicase conserved C-terminal domain

cd12873
Location:93 → 246

SPRY_DDX1; SPRY domain associated with DEAD box gene DDX1

cl21455
Location:284 → 426

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases