pkdcc.S protein kinase domain containing, cytoplasmic, gene 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pkdcc.S
Official Full Name: protein kinase domain containing, cytoplasmic, gene 1 S homeolog
Primary source: Xenbase:XB-GENE-6079362
Locus tag: XELAEV_18041206mg
See related: EnsemblRapid:ENSXLAG00005004819 AllianceGenome:Xenbase:XB-GENE-6079362
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: vlk; pkdcc; pkdcc1; sgk493; pkdcc.1; pkdcc.1.S
Summary: Predicted to enable ATP binding activity and non-membrane spanning protein tyrosine kinase activity. Predicted to act upstream of or within peptidyl-tyrosine phosphorylation and skeletal system development. Predicted to be located in extracellular region. Is expressed in cardiovascular system; nervous system; and primary germ layer. Orthologous to human PKDCC (protein kinase domain containing, cytoplasmic). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8S

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8S	NC_054386.1 (12687588..12703349, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8S	NC_030739.1 (12591834..12633125, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	Unplaced Scaffold	NW_016702921.1 (747..1006, complement)

Chromosome 8S - NC_054386.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Study identified two new PKDCC genes, Pkdcc1 and Pkdcc2 from Xenopus laevis. They seem involved on blastopore and neural tube closure during gastrula and neurula stages, respectively. Also, they seem to regulate JNK dependent Wnt/PCP signaling.
Title: Xenopus Pkdcc1 and Pkdcc2 Are Two New Tyrosine Kinases Involved in the Regulation of JNK Dependent Wnt/PCP Signaling Pathway.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within peptidyl-tyrosine phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skeletal system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein kinase domain containing, cytoplasmic homolog, gene 1

Names: protein kinase domain containing, cytoplasmic homolog, gene 1 S homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001097762.2 → NP_001091231.2 protein kinase domain containing, cytoplasmic homolog, gene 1

Status: VALIDATED

Source sequence(s)

BC130129

UniProtKB/TrEMBL

A0A8J0Q7A3, A1L3J2

Related

ENSXLAP00005014401.1, ENSXLAT00005014597.1

Conserved Domains (1) summary

cl21453
Location:177 → 315

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054386.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

12687588..12703349 complement

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GenBank, FASTA, Sequence Viewer (Graphics)