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birc2.S baculoviral IAP repeat containing 2 S homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 100036859, updated on 18-Sep-2024

Summary

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Official Symbol
birc2.S
Official Full Name
baculoviral IAP repeat containing 2 S homeolog
Primary source
Xenbase:XB-GENE-17343783
Locus tag
XELAEV_18016254mg
See related
EnsemblRapid:ENSXLAG00005020813
Gene type
protein coding
RefSeq status
PREDICTED
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
api1; mihb; ciap1; hiap2; rnf48; c-iap1; hiap-2
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Genomic context

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See birc2.S in Genome Data Viewer
Location:
chromosome: 2S
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2S NC_054374.1 (150704278..150746287)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2S NC_030727.1 (141736207..141755533)

Chromosome 2S - NC_054374.1Genomic Context describing neighboring genes Neighboring gene protein mono-ADP-ribosyltransferase PARP4 Neighboring gene centrosomal protein of 126 kDa-like Neighboring gene Yes associated protein 1 S homeolog Neighboring gene transmembrane protein 123 S homeolog Neighboring gene matrix metalloproteinase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables cysteine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of necroptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of programmed cell death IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
uncharacterized protein LOC100036859

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097144.1 → NP_001090613.1  uncharacterized protein LOC100036859

    See identical proteins and their annotated locations for NP_001090613.1

    Status: PREDICTED

    Source sequence(s)
    BC129545
    UniProtKB/TrEMBL
    A1L2I6
    Conserved Domains (5) summary
    smart00238
    Location:31 → 101
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:252 → 319
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:371 → 420
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    pfam13920
    Location:548 → 593
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl14633
    Location:431 → 525
    DD; Death Domain Superfamily of protein-protein interaction domains

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054374.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    150704278..150746287
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041582906.1 → XP_041438840.1  uncharacterized protein LOC100036859 isoform X1

    UniProtKB/TrEMBL
    A0A1L8HAT1, A0A974DJP2
    Related
    ENSXLAP00005061100.1, ENSXLAT00005062553.1
    Conserved Domains (6) summary
    smart00238
    Location:41 → 111
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:262 → 329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:381 → 430
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:556 → 609
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:178 → 242
    BIR; Inhibitor of Apoptosis domain
    cl14633
    Location:441 → 535
    DD; Death Domain Superfamily of protein-protein interaction domains

  2. XM_041582905.1 → XP_041438839.1  uncharacterized protein LOC100036859 isoform X1

    UniProtKB/TrEMBL
    A0A1L8HAT1, A0A974DJP2
    Conserved Domains (6) summary
    smart00238
    Location:41 → 111
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:262 → 329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:381 → 430
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:556 → 609
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:178 → 242
    BIR; Inhibitor of Apoptosis domain
    cl14633
    Location:441 → 535
    DD; Death Domain Superfamily of protein-protein interaction domains

  3. XM_041582907.1 → XP_041438841.1  uncharacterized protein LOC100036859 isoform X2

    UniProtKB/TrEMBL
    A0A8J1MBV8
    Related
    ENSXLAP00005061118.1, ENSXLAT00005062570.1
    Conserved Domains (6) summary
    smart00238
    Location:41 → 111
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:262 → 329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:381 → 430
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:542 → 595
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:178 → 242
    BIR; Inhibitor of Apoptosis domain
    cl14633
    Location:441 → 531
    DD; Death Domain Superfamily of protein-protein interaction domains

  4. XM_041582904.1 → XP_041438838.1  uncharacterized protein LOC100036859 isoform X1

    UniProtKB/TrEMBL
    A0A1L8HAT1, A0A974DJP2
    Related
    ENSXLAP00005061112.1, ENSXLAT00005062564.1
    Conserved Domains (6) summary
    smart00238
    Location:41 → 111
    BIR; Baculoviral inhibition of apoptosis protein repeat
    cd00022
    Location:262 → 329
    BIR; Baculoviral inhibition of apoptosis protein repeat domain; Found in inhibitors of apoptosis proteins (IAPs) and other proteins. In higher eukaryotes, BIR domains inhibit apoptosis by acting as direct inhibitors of the caspase family of protease enzymes. ...
    cd14394
    Location:381 → 430
    UBA_BIRC2_3; UBA domain found in baculoviral IAP repeat-containing protein BIRC2, BIRC3 and similar proteins
    cd16713
    Location:556 → 609
    RING-HC_BIRC2_3_7; RING finger, HC subclass, found in apoptosis protein c-IAP1, c-IAP2, livin, and similar proteins
    pfam00653
    Location:178 → 242
    BIR; Inhibitor of Apoptosis domain
    cl14633
    Location:441 → 535
    DD; Death Domain Superfamily of protein-protein interaction domains
Nucleotide Protein Strain
Heading Accession and Version

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