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st8sia5 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 100036735, updated on 14-Nov-2024

Summary

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Official Symbol
st8sia5provided by Xenbase
Official Full Name
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5provided by Xenbase
Primary source
Xenbase:XB-GENE-988459
See related
Ensembl:ENSXETG00000039548 AllianceGenome:Xenbase:XB-GENE-988459
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Summary
Predicted to enable sialyltransferase activity. Predicted to act upstream of or within protein glycosylation. Predicted to be located in Golgi membrane. Orthologous to human ST8SIA5 (ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See st8sia5 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
8
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 1 NC_030677.2 (206981814..207016857, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 1 NC_030677.1 (193530877..193570791, complement)

Chromosome 1 - NC_030677.2Genomic Context describing neighboring genes Neighboring gene arkadia (RNF111) C-terminal like ring finger ubiquitin ligase 2C Neighboring gene lipoxygenase homology PLAT domains 1 Neighboring gene sialic acid binding Ig like lectin 15 Neighboring gene solute carrier family 14 (urea transporter), member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary history of the alpha2,8-sialyltransferase (ST8Sia) gene family: tandem duplications in early deuterostomes explain most of the diversity found in the vertebrate ST8Sia genes. Harduin-Lepers A, et al. BMC Evol Biol, 2008 Sep 23. PMID 18811928, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables sialyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in N-glycan processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in oligosaccharide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-2,8-sialyltransferase 8E
Names
alpha-2,8-sialyltransferase ST8Sia V
siat 8E
NP_001090748.1
XP_012812330.1
XP_012812371.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097279.1 → NP_001090748.1  alpha-2,8-sialyltransferase 8E

    See identical proteins and their annotated locations for NP_001090748.1

    Status: PROVISIONAL

    Source sequence(s)
    AM422136
    UniProtKB/TrEMBL
    A2BCP7
    Conserved Domains (1) summary
    pfam00777
    Location:117 → 371
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030677.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    206981814..207016857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012956876.3 → XP_012812330.1  alpha-2,8-sialyltransferase 8E isoform X1

    UniProtKB/TrEMBL
    A0A6I8S6X4
    Related
    ENSXETP00000090573.1, ENSXETT00000069571.2
    Conserved Domains (1) summary
    pfam00777
    Location:153 → 406
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)

  2. XM_012956917.3 → XP_012812371.1  alpha-2,8-sialyltransferase 8E isoform X2

    UniProtKB/TrEMBL
    A0A8J0SCJ0
    Conserved Domains (1) summary
    pfam00777
    Location:117 → 370
    Glyco_transf_29; Glycosyltransferase family 29 (sialyltransferase)
Nucleotide Protein Strain
Heading Accession and Version

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