IL12B interleukin 12B [Equus caballus (horse)] - Gene

Summary

Official Symbol: IL12Bprovided by VGNC
Official Full Name: interleukin 12Bprovided by VGNC
Primary source: VGNC:VGNC:18994
See related: Ensembl:ENSECAG00000012803
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
103	current	EquCab3.0 (GCF_002863925.1)	14	NC_009157.3 (19326161..19334661)
102	previous assembly	EquCab2.0 (GCF_000002305.2)	14	NC_009157.2 (20194970..20203470)

Chromosome 14 - NC_009157.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

IL12B (e-PCR), detects polymorphism
- UniSTS:504981

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine receptor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cytokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immunoglobulin mediated immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-12 subunit beta

Names: CLMF p40; IL-12 p40; IL-12 subunit p40; IL-12B; cytotoxic lymphocyte maturation factor 40 kDa subunit; interleukin 12 p40 subunit; interleukin 12 subunit p40; interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082516.1 → NP_001075985.1 interleukin-12 subunit beta precursor

See identical proteins and their annotated locations for NP_001075985.1

Status: PROVISIONAL

Source sequence(s)

Y11129

UniProtKB/Swiss-Prot

Q9XSQ5

UniProtKB/TrEMBL

F6RIY4

Related

ENSECAP00000010803.1, ENSECAT00000013594.3

Conserved Domains (3) summary

smart00408
Location:42 → 90

IGc2; Immunoglobulin C-2 Type

cd00063
Location:236 → 326

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam10420
Location:126 → 217

IL12p40_C; Cytokine interleukin-12p40 C-terminus