IL10 interleukin 10 [Equus caballus (horse)] - Gene

Summary

Official Symbol: IL10provided by VGNC
Official Full Name: interleukin 10provided by VGNC
Primary source: VGNC:VGNC:50843
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: IL-10
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	5	NC_009148.3 (2994056..3005320, complement)

Chromosome 5 - NC_009148.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:: NC_009148.3 Chromosome 5 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The ability of an EHV-1 isolate to down-regulate IL-10 production might contribute to increased local inflammation and a higher risk for neurological manifestation of the disease after infection with Ab4.
Title: Infection of peripheral blood mononuclear cells with neuropathogenic equine herpesvirus type-1 strain Ab4 reveals intact interferon-α induction and induces suppression of anti-inflammatory interleukin-10 responses in comparison to other viral strains.
The data suggested in foals there is an impaired Th2 response, the immune response is Th1 biased, interferon-gamma production is qualitatively similar to adult horses, and regulatory IL-10 production by T cells is mature.
Title: Interferon-gamma, interleukin-4 and interleukin-10 production by T helper cells reveals intact Th1 and regulatory TR1 cell activation and a delay of the Th2 cell response in equine neonates and foals.
serum IL-6:IL-10 ratio is likely to provide a valuable prognosticator for neonatal septicemia
Title: Serum interleukin-6 (IL-6) and IL-10 concentrations in normal and septic neonatal foals.
The contribution of bronchial epithelium to airway inflammation, with focus on mRNA and protein expression of IL-6, IL-10 and TNF-alpha, in horses with recurrent airway obstruction during exacerbation and in remission is reported.
Title: Epithelial expression of mRNA and protein for IL-6, IL-10 and TNF-alpha in endobronchial biopsies in horses with recurrent airway obstruction.
The effect of clenbuterol on cytokine metabolism in the peripheral white blood cells in those horses with small airway diseases that have been exposed to lipopolysaccharides is reported.
Title: Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharides.

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General gene information

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Markers

Il10 (e-PCR), detects polymorphism
- UniSTS:143532

IL10 (e-PCR), detects polymorphism
- UniSTS:503729

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: interleukin-10

Names: CSIF; cytokine synthesis inhibitory factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.