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PFKM phosphofructokinase, muscle [ Equus caballus (horse) ]

Gene ID: 100034116, updated on 17-Aug-2024

Summary

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Official Symbol
PFKMprovided by VGNC
Official Full Name
phosphofructokinase, muscleprovided by VGNC
Primary source
VGNC:VGNC:56593
See related
Ensembl:ENSECAG00000015087
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Equus caballus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as
PFK-A; PFK-M; ATP-PFK
Orthologs
human mouse all
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Genomic context

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See PFKM in Genome Data Viewer
Location:
chromosome: 6
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current EquCab3.0 (GCF_002863925.1) 6 NC_009149.3 (66636439..66678672)

Chromosome 6 - NC_009149.3Genomic Context describing neighboring genes Neighboring gene collagen type II alpha 1 chain Neighboring gene SUMO specific peptidase 1 Neighboring gene serine/threonine/tyrosine-interacting protein pseudogene Neighboring gene ERO1-like protein alpha Neighboring gene ankyrin repeat and SOCS box containing 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_009149.3 Chromosome 6 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning of equine muscle-type phosphofructokinase cDNA. Sato T, et al. J Vet Med Sci, 2003 May. PMID 12808221
  2. Molecular characterization of glycogen synthase 1 and its tissue expression profile with type II hexokinase and muscle-type phosphofructokinase in horses. Echigoya Y, et al. Mol Biol Rep, 2011 Jan. PMID 20383748
  3. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The tissue expression profiles of eGYS1, equine type II hexokinase (eHKII) and muscle-type phosphofructokinase (ePFKM) were determined by real-time PCR and western blot analysis.
    Title: Molecular characterization of glycogen synthase 1 and its tissue expression profile with type II hexokinase and muscle-type phosphofructokinase in horses.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables 6-phosphofructokinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables AMP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables fructose-6-phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables monosaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in canonical glycolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fructose 1,6-bisphosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in fructose 6-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of 6-phosphofructokinase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
ATP-dependent 6-phosphofructokinase, muscle type
Names
6-phosphofructokinase type A
6-phosphofructokinase, muscle type
muscle type phosphofructokinase
phosphofructo-1-kinase isozyme A
phosphofructokinase 1
phosphofructokinase-M
phosphohexokinase
NP_001075391.1
XP_005611133.1
XP_014596234.1
XP_023497935.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081922.2 → NP_001075391.1  ATP-dependent 6-phosphofructokinase, muscle type

    See identical proteins and their annotated locations for NP_001075391.1

    Status: VALIDATED

    Source sequence(s)
    AB088683, CX601578
    UniProtKB/Swiss-Prot
    Q867C9
    UniProtKB/TrEMBL
    A0A9L0STA5
    Conserved Domains (2) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:16 → 755
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type

RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference EquCab3.0 Primary Assembly

Genomic

  1. NC_009149.3 Reference EquCab3.0 Primary Assembly

    Range
    66636439..66678672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_014740748.1 → XP_014596234.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X1

    UniProtKB/TrEMBL
    A0A3Q2GST7, A0A9L0STA5
    Related
    ENSECAP00000023635.3, ENSECAT00000037447.3
    Conserved Domains (2) summary
    cd00764
    Location:84 → 845
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:87 → 826
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type

  2. XM_023642167.1 → XP_023497935.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X2

    UniProtKB/TrEMBL
    A0A3Q2H8U7, A0A9L0STA5
    Related
    ENSECAP00000030377.2, ENSECAT00000055750.3
    Conserved Domains (1) summary
    cd00764
    Location:43 → 804
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...

  3. XM_005611076.3 → XP_005611133.1  ATP-dependent 6-phosphofructokinase, muscle type isoform X3

    See identical proteins and their annotated locations for XP_005611133.1

    UniProtKB/TrEMBL
    A0A9L0RR79, A0A9L0STA5
    Related
    ENSECAP00000066375.1, ENSECAT00000087219.1
    Conserved Domains (2) summary
    cd00764
    Location:13 → 774
    Eukaryotic_PFK; Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent ...
    TIGR02478
    Location:16 → 755
    6PF1K_euk; 6-phosphofructokinase, eukaryotic type
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q867C9.3 GenPept UniProtKB/Swiss-Prot:Q867C9

Gene LinkOut

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