TIMP3 TIMP metallopeptidase inhibitor 3 [Equus caballus (horse)] - Gene

Summary

Official Symbol: TIMP3provided by VGNC
Official Full Name: TIMP metallopeptidase inhibitor 3provided by VGNC
Primary source: VGNC:VGNC:24109
See related: Ensembl:ENSECAG00000018314
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Equus caballus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
Also known as: TIMP-3
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 28

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	EquCab3.0 (GCF_002863925.1)	28	NC_009171.3 (32034573..32089052)

Chromosome 28 - NC_009171.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_009171.3 Chromosome 28 Reference EquCab3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

REN79695 (e-PCR)
- UniSTS:404493

Timp3 (e-PCR), detects polymorphism
- UniSTS:265762

ECD10386 (e-PCR)
- UniSTS:291425

D22S979E (e-PCR)
- UniSTS:88515

TIMP3 (e-PCR)
- UniSTS:506321

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protease binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of membrane protein ectodomain proteolysis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to cytokine	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to hormone	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: metalloproteinase inhibitor 3

Names: tissue inhibitor of metalloproteinase 3; tissue inhibitor of metalloproteinases 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001081870.2 → NP_001075339.1 metalloproteinase inhibitor 3 precursor

See identical proteins and their annotated locations for NP_001075339.1

Status: VALIDATED

Source sequence(s)

PJAA01000029

UniProtKB/Swiss-Prot

Q9TUL9

UniProtKB/TrEMBL

A0A9R8NB31

Related

ENSECAP00000075183.1, ENSECAT00000084385.1

Conserved Domains (1) summary

cd03585
Location:24 → 200

NTR_TIMP; NTR domain, TIMP subfamily; TIMPs, or tissue inibitors of metalloproteases, are essential regulators of extracellular matrix turnover and remodeling. They form complexes with matrix metalloproteases (MMPs) and inactivate them irreversibly by ...