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PLEC plectin [ Monodelphis domestica (gray short-tailed opossum) ]

Gene ID: 100014955, updated on 10-Oct-2024

Summary

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Gene symbol
PLEC
Gene description
plectin
See related
EnsemblRapid:ENSMODG00000010370
Gene type
protein coding
RefSeq status
MODEL
Organism
Monodelphis domestica
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Metatheria; Didelphimorphia; Didelphidae; Monodelphis
Orthologs
human mouse all
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Genomic context

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See PLEC in Genome Data Viewer
Location:
chromosome: 3
Exon count:
43
Annotation release Status Assembly Chr Location
RS_2023_05 current mMonDom1.pri (GCF_027887165.1) 3 NC_077229.1 (101791815..101911471, complement)
103 previous assembly MonDom5 (GCF_000002295.2) 3 NC_008803.1 (434762717..434882563, complement)

Chromosome 3 - NC_077229.1Genomic Context describing neighboring genes Neighboring gene microtubule-actin cross-linking factor 1 Neighboring gene epiplakin 1 Neighboring gene uncharacterized LOC103093486 Neighboring gene poly(ADP-ribose) polymerase family member 10 Neighboring gene glutamate ionotropic receptor NMDA type subunit associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ankyrin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables cadherin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables keratin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of muscle IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in hemidesmosome assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intermediate filament bundle assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in wound healing IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in hemidesmosome IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in keratin filament IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in sarcolemma IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
plectin

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_027887165.1-RS_2023_05

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference mMonDom1.pri

Genomic

  1. NC_077229.1 Reference mMonDom1.pri

    Range
    101791815..101911471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_007488713.3 → XP_007488775.1  plectin isoform X11

    UniProtKB/TrEMBL
    F6TAJ1
    Conserved Domains (11) summary
    smart00250
    Location:3125 → 3161
    PLEC; Plectin repeat
    cd00014
    Location:70 → 172
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:646 → 835
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:990 → 1817
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:187 → 285
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2835 → 2876
    Plectin; Plectin repeat
    pfam01576
    Location:1477 → 2494
    Myosin_tail_1; Myosin tail
    cd16269
    Location:2360 → 2373
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1382 → 1481
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2235 → 2393
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1499 → 1568
    ATP-synt_B; ATP synthase B/B' CF(0)

  2. XM_016432017.2 → XP_016287503.1  plectin isoform X9

    UniProtKB/TrEMBL
    F6TAJ1

  3. XM_016432016.2 → XP_016287502.1  plectin isoform X8

    UniProtKB/TrEMBL
    F6TAJ1
    Related
    ENSMODP00000075206.1, ENSMODT00000153063.1

  4. XM_056822864.1 → XP_056678842.1  plectin isoform X26

  5. XM_056822863.1 → XP_056678841.1  plectin isoform X23

    Related
    ENSMODP00000069439.1, ENSMODT00000091564.1

  6. XM_016432025.2 → XP_016287511.1  plectin isoform X20

    UniProtKB/TrEMBL
    F6TAJ1

  7. XM_016432024.2 → XP_016287510.1  plectin isoform X18

    UniProtKB/TrEMBL
    F6TAJ1

  8. XM_056822861.1 → XP_056678839.1  plectin isoform X7

    Related
    ENSMODP00000085727.1, ENSMODT00000094659.1

  9. XM_016432027.2 → XP_016287513.2  plectin isoform X6

  10. XM_016432026.2 → XP_016287512.2  plectin isoform X5

  11. XM_007488711.3 → XP_007488773.1  plectin isoform X4

    UniProtKB/TrEMBL
    F6TAJ1
    Related
    ENSMODP00000088212.1, ENSMODT00000090614.1
    Conserved Domains (13) summary
    smart00250
    Location:3235 → 3271
    PLEC; Plectin repeat
    cd00014
    Location:180 → 282
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:756 → 945
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1100 → 1927
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:297 → 395
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2945 → 2986
    Plectin; Plectin repeat
    pfam01576
    Location:1587 → 2604
    Myosin_tail_1; Myosin tail
    pfam03501
    Location:7 → 102
    S10_plectin; Plectin/S10 domain
    pfam10211
    Location:2578 → 2674
    Ax_dynein_light; Axonemal dynein light chain
    cd16269
    Location:2470 → 2483
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1492 → 1591
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2345 → 2503
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1609 → 1678
    ATP-synt_B; ATP synthase B/B' CF(0)

  12. XM_016432015.2 → XP_016287501.1  plectin isoform X2

    UniProtKB/TrEMBL
    F6TAJ1

  13. XM_007488710.3 → XP_007488772.1  plectin isoform X3

    UniProtKB/TrEMBL
    F6TAJ1
    Conserved Domains (13) summary
    smart00250
    Location:3240 → 3276
    PLEC; Plectin repeat
    cd00014
    Location:180 → 287
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:761 → 950
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:1105 → 1932
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:302 → 400
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2950 → 2991
    Plectin; Plectin repeat
    pfam01576
    Location:1592 → 2609
    Myosin_tail_1; Myosin tail
    pfam03501
    Location:7 → 102
    S10_plectin; Plectin/S10 domain
    pfam10211
    Location:2583 → 2679
    Ax_dynein_light; Axonemal dynein light chain
    cd16269
    Location:2475 → 2488
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1497 → 1596
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2350 → 2508
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1614 → 1683
    ATP-synt_B; ATP synthase B/B' CF(0)

  14. XM_016432014.2 → XP_016287500.1  plectin isoform X1

    UniProtKB/TrEMBL
    F6TAJ1

  15. XM_016432029.2 → XP_016287515.1  plectin isoform X25

    UniProtKB/TrEMBL
    F6TAJ1

  16. XM_016432028.2 → XP_016287514.1  plectin isoform X24

    UniProtKB/TrEMBL
    F6TAJ1
    Related
    ENSMODP00000063968.1, ENSMODT00000154204.1

  17. XM_007488719.3 → XP_007488781.1  plectin isoform X22

    UniProtKB/TrEMBL
    F6TAJ1
    Conserved Domains (11) summary
    smart00250
    Location:3098 → 3134
    PLEC; Plectin repeat
    cd00014
    Location:43 → 145
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:619 → 808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:963 → 1790
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:160 → 258
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2808 → 2849
    Plectin; Plectin repeat
    pfam01576
    Location:1450 → 2467
    Myosin_tail_1; Myosin tail
    cd16269
    Location:2333 → 2346
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1355 → 1454
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2208 → 2366
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1472 → 1541
    ATP-synt_B; ATP synthase B/B' CF(0)

  18. XM_016432023.2 → XP_016287509.1  plectin isoform X16

    UniProtKB/TrEMBL
    F6TAJ1

  19. XM_007488717.3 → XP_007488779.1  plectin isoform X19

    UniProtKB/TrEMBL
    F6TAJ1
    Related
    ENSMODP00000065656.1, ENSMODT00000142261.1
    Conserved Domains (11) summary
    smart00250
    Location:3103 → 3139
    PLEC; Plectin repeat
    cd00014
    Location:43 → 150
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:624 → 813
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:968 → 1795
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:165 → 263
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2813 → 2854
    Plectin; Plectin repeat
    pfam01576
    Location:1455 → 2472
    Myosin_tail_1; Myosin tail
    cd16269
    Location:2338 → 2351
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1360 → 1459
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2213 → 2371
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1477 → 1546
    ATP-synt_B; ATP synthase B/B' CF(0)

  20. XM_016432021.2 → XP_016287507.1  plectin isoform X13

    UniProtKB/TrEMBL
    F6TAJ1

  21. XM_016432019.2 → XP_016287505.1  plectin isoform X12

    UniProtKB/TrEMBL
    F6TAJ1

  22. XM_016432018.2 → XP_016287504.1  plectin isoform X10

    UniProtKB/TrEMBL
    F6TAJ1

  23. XM_007488715.2 → XP_007488777.1  plectin isoform X17

    UniProtKB/TrEMBL
    F6TAJ1
    Related
    ENSMODP00000067130.1, ENSMODT00000141412.1
    Conserved Domains (11) summary
    smart00250
    Location:3109 → 3145
    PLEC; Plectin repeat
    cd00014
    Location:54 → 156
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:630 → 819
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:974 → 1801
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:171 → 269
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2819 → 2860
    Plectin; Plectin repeat
    pfam01576
    Location:1461 → 2478
    Myosin_tail_1; Myosin tail
    cd16269
    Location:2344 → 2357
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1366 → 1465
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2219 → 2377
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1483 → 1552
    ATP-synt_B; ATP synthase B/B' CF(0)

  24. XM_016432022.2 → XP_016287508.1  plectin isoform X15

    UniProtKB/TrEMBL
    F6TAJ1

  25. XM_016432020.2 → XP_016287506.1  plectin isoform X14

    UniProtKB/TrEMBL
    F6TAJ1

  26. XM_007488718.3 → XP_007488780.1  plectin isoform X21

    UniProtKB/TrEMBL
    F6TAJ1
    Related
    ENSMODP00000084850.1, ENSMODT00000098601.1
    Conserved Domains (11) summary
    smart00250
    Location:3098 → 3134
    PLEC; Plectin repeat
    cd00014
    Location:43 → 145
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    cd00176
    Location:619 → 808
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    TIGR02168
    Location:963 → 1790
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam00307
    Location:160 → 258
    CH; Calponin homology (CH) domain
    pfam00681
    Location:2808 → 2849
    Plectin; Plectin repeat
    pfam01576
    Location:1450 → 2467
    Myosin_tail_1; Myosin tail
    cd16269
    Location:2333 → 2346
    GBP_C; coiled coil [structural motif]
    cl19107
    Location:1355 → 1454
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl20817
    Location:2208 → 2366
    GBP_C; Guanylate-binding protein, C-terminal domain
    cl21478
    Location:1472 → 1541
    ATP-synt_B; ATP synthase B/B' CF(0)
Nucleotide Protein
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