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mto1 mitochondrial tRNA translation optimization 1 [ Danio rerio (zebrafish) ]

Gene ID: 100009640, updated on 12-Sep-2024

Summary

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Official Symbol
mto1provided by ZNC
Official Full Name
mitochondrial tRNA translation optimization 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070209-253
See related
Ensembl:ENSDARG00000055679 AllianceGenome:ZFIN:ZDB-GENE-070209-253
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:158782
Summary
Predicted to enable flavin adenine dinucleotide binding activity. Predicted to be involved in mitochondrial tRNA wobble uridine modification and tRNA methylation. Predicted to act upstream of or within tRNA processing. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 10. Orthologous to human MTO1 (mitochondrial tRNA translation optimization 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See mto1 in Genome Data Viewer
Location:
chromosome: 12
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 12 NC_007123.7 (14211364..14310116)
105 previous assembly GRCz10 (GCF_000002035.5) 12 NC_007123.6 (14173243..14271813)

Chromosome 12 - NC_007123.7Genomic Context describing neighboring genes Neighboring gene kelch repeat and BTB (POZ) domain containing 2 Neighboring gene uncharacterized LOC110440141 Neighboring gene AVL9 homolog (S. cerevisiase) Neighboring gene uncharacterized LOC110440140 Neighboring gene antifreeze protein Maxi-like Neighboring gene uncharacterized LOC137496800 Neighboring gene beclin 1, autophagy related

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Multiplicity of Buc copies in Atlantic salmon contrasts with loss of the germ cell determinant in primates, rodents and axolotl. Škugor A, et al. BMC Evol Biol, 2016 Oct 26. PMID 27784263, Free PMC Article
  2. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Zhang Q, et al. Nucleic Acids Res, 2021 May 7. PMID 33836087, Free PMC Article
  3. Deletion of Gtpbp3 in zebrafish revealed the hypertrophic cardiomyopathy manifested by aberrant mitochondrial tRNA metabolism. Chen D, et al. Nucleic Acids Res, 2019 Jun 4. PMID 30916346, Free PMC Article
  4. What makes a bad egg? Egg transcriptome reveals dysregulation of translational machinery and novel fertility genes important for fertilization. Cheung CT, et al. BMC Genomics, 2019 Jul 15. PMID 31307377, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
    Title: Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial tRNA wobble uridine modification IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within tRNA processing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within tRNA wobble uridine modification IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
protein MTO1 homolog, mitochondrial
Names
mitochondrial translation optimization 1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083009.1 → NP_001076478.1  protein MTO1 homolog, mitochondrial

    See identical proteins and their annotated locations for NP_001076478.1

    Status: PROVISIONAL

    Source sequence(s)
    BC133157
    UniProtKB/TrEMBL
    A2RV35
    Related
    ENSDARP00000072515.3, ENSDART00000078052.5
    Conserved Domains (3) summary
    PRK05192
    Location:23 → 646
    PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
    pfam13932
    Location:435 → 644
    GIDA_assoc; GidA associated domain
    cl21454
    Location:351 → 423
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007123.7 Reference GRCz11 Primary Assembly

    Range
    14211364..14310116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009306471.4 → XP_009304746.1  protein MTO1 homolog, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8M3B787
    Conserved Domains (3) summary
    PRK05192
    Location:59 → 682
    PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
    pfam13932
    Location:471 → 680
    GIDA_assoc; GidA associated domain
    cl21454
    Location:387 → 459
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_009306472.4 → XP_009304747.1  protein MTO1 homolog, mitochondrial isoform X2

    See identical proteins and their annotated locations for XP_009304747.1

    UniProtKB/TrEMBL
    A0A8M3B4F4, F1R509
    Conserved Domains (3) summary
    PRK05192
    Location:23 → 646
    PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
    pfam13932
    Location:435 → 644
    GIDA_assoc; GidA associated domain
    cl21454
    Location:351 → 423
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_068224475.1 → XP_068080576.1  protein MTO1 homolog, mitochondrial isoform X2

  4. XM_021480003.2 → XP_021335678.1  protein MTO1 homolog, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8M9QE21
    Conserved Domains (1) summary
    PRK05192
    Location:1 → 557
    PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated

  5. XM_021480004.2 → XP_021335679.1  protein MTO1 homolog, mitochondrial isoform X3

    UniProtKB/TrEMBL
    A0A8M9QE21
    Conserved Domains (1) summary
    PRK05192
    Location:1 → 557
    PRK05192; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated
Nucleotide Protein Strain
Heading Accession and Version

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