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IL1RN interleukin 1 receptor antagonist [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009558, updated on 8-Mar-2024

Summary

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Gene symbol
IL1RN
Gene description
interleukin 1 receptor antagonist
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
IL1RA; icIL-1ra
Annotation information
Annotation category: partial on reference assembly
Orthologs
human mouse all
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Genomic context

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See IL1RN in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 2 NC_067375.1 (98263144..98268689)

Chromosome 2 - NC_067375.1Genomic Context describing neighboring genes Neighboring gene interleukin 36 receptor antagonist Neighboring gene interleukin 1 family member 10 Neighboring gene pleckstrin and Sec7 domain containing 4 Neighboring gene paired box 8

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067375.1 Chromosome 2 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rabbit interleukin-1 receptor antagonist. Cloning, expression, functional characterization, and regulation during intestinal inflammation. Cominelli F, et al. J Biol Chem, 1994 Mar 4. PMID 7509813
  2. Interleukin-1 receptor antagonist in inflammatory exudate cells of rabbits. Production, purification and determination of primary structure. Goto F, et al. Immunology, 1992 Oct. PMID 1427977, Free PMC Article
  3. Correlation of neutrophil and monocyte derived interleukin-1 receptor antagonist and interleukin-8 with colitis severity in the rabbit. Kaneda K, et al. Cytokine, 2011 Nov. PMID 21807533
  4. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  5. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cytokine activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-1 receptor antagonist activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables interleukin-1 receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in inflammatory response to antigenic stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in negative regulation of interleukin-1-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
interleukin-1 receptor antagonist protein
Names
IL-1RN
IL-1ra
IL1 inhibitor
IRAP
interleukin 1 receptor, type I
interleukin-1 receptor antagonist intracellular form

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082770.1 → NP_001076239.1  interleukin-1 receptor antagonist protein precursor

    See identical proteins and their annotated locations for NP_001076239.1

    Status: PROVISIONAL

    Source sequence(s)
    M57526
    UniProtKB/Swiss-Prot
    P26890
    Conserved Domains (1) summary
    smart00125
    Location:33 → 174
    IL1; Interleukin-1 homologues

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067375.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    98263144..98268689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P26890.1 GenPept UniProtKB/Swiss-Prot:P26890

Gene LinkOut

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