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LOC100009428 troponin T, cardiac muscle [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009428, updated on 10-Oct-2024

Summary

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Gene symbol
LOC100009428
Gene description
troponin T, cardiac muscle
See related
Ensembl:ENSOCUG00000007730
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
LAD1; TNNT2
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Genomic context

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See LOC100009428 in Genome Data Viewer
Location:
chromosome: 16
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 16 NC_067389.1 (15378499..15409988, complement)

Chromosome 16 - NC_067389.1Genomic Context describing neighboring genes Neighboring gene immunoglobulin like and fibronectin type III domain containing 1 Neighboring gene plakophilin 1 Neighboring gene troponin I1, slow skeletal type Neighboring gene pleckstrin homology like domain family A member 3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067389.1 Chromosome 16 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. [Expression of cTnT in rabbit hearts during myocardial ischemia and its postmortem stability]. Xiong XM, et al. Fa Yi Xue Za Zhi, 2008 Apr. PMID 18605035
  2. Molecular basis of cardiac troponin T isoform heterogeneity in rabbit heart. Greig A, et al. Circ Res, 1994 Jan. PMID 8261593
  3. Isolation and some properties of troponin T kinase from rabbit skeletal muscle. Gusev NB, et al. Biochem J, 1980 Aug 1. PMID 7458911, Free PMC Article
  4. Amino acid sequence of rabbit cardiac troponin T. Pearlstone JR, et al. J Biol Chem, 1986 Dec 25. PMID 3782144
  5. Acrylodan-labeled smooth muscle tropomyosin reports differences in the effects of troponin and caldesmon in the transition from the active state to the inactive state. Chalovich JM, et al. Biochemistry, 2011 Jul 12. PMID 21639115, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Substituting smooth muscle caldesmon for skeletal muscle troponin produces a similar decrease and re-increase in fluorescence, but the apparent rate constant for the increase is >10 times that observed with troponin.
    Title: Acrylodan-labeled smooth muscle tropomyosin reports differences in the effects of troponin and caldesmon in the transition from the active state to the inactive state.
  2. In ischemic myocardium, the expression of cTnT showed prominent focal or flaky depletion in myocardial cytoplasm with no expression detected in interstitium.
    Title: [Expression of cTnT in rabbit hearts during myocardial ischemia and its postmortem stability].
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables tropomyosin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables troponin C binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables troponin I binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cardiac muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sarcomere organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
troponin T, cardiac muscle
Names
ladinin 1
troponin T type 2 (cardiac)
troponin T2, cardiac type

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067389.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    15378499..15409988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051820478.1 → XP_051676438.1  troponin T, cardiac muscle isoform X5

  2. XM_051820477.1 → XP_051676437.1  troponin T, cardiac muscle isoform X4

  3. XM_051820479.1 → XP_051676439.1  troponin T, cardiac muscle isoform X6

  4. XM_051820480.1 → XP_051676440.1  troponin T, cardiac muscle isoform X7

  5. XM_051820476.1 → XP_051676436.1  troponin T, cardiac muscle isoform X3

  6. XM_051820475.1 → XP_051676435.1  troponin T, cardiac muscle isoform X2

  7. XM_008268604.3 → XP_008266826.1  troponin T, cardiac muscle isoform X1

    UniProtKB/TrEMBL
    G1STN8
    Related
    ENSOCUP00000006683.3
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09741.3 GenPept UniProtKB/Swiss-Prot:P09741

Gene LinkOut

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