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APOA1 apolipoprotein A1 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009253, updated on 8-Mar-2024

Summary

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Gene symbol
APOA1
Gene description
apolipoprotein A1
See related
Ensembl:ENSOCUG00000010728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See APOA1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 1 NC_067374.1 (113563114..113564779)

Chromosome 1 - NC_067374.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127491677 Neighboring gene SIK family kinase 3 Neighboring gene ubiquitin carboxyl-terminal hydrolase isozyme L3-like Neighboring gene apolipoprotein C3 Neighboring gene apolipoprotein A4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067374.1 Chromosome 1 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis. Wacker BK, et al. Arterioscler Thromb Vasc Biol, 2017 Feb. PMID 27932352, Free PMC Article
  2. Antioxidant effect of apolipoprotein A-I on high-fat diet-induced non-alcoholic fatty liver disease in rabbits. Wang W, et al. Acta Biochim Biophys Sin (Shanghai), 2013 Feb. PMID 23174676
  3. Rabbit apolipoprotein A-I mRNA and gene. Evidence that rabbit apolipoprotein A-I is synthesized in the intestine but not in the liver. Pan TC, et al. Eur J Biochem, 1987 Dec 30. PMID 3121329
  4. The primary structure of apolipoprotein A-I from rabbit high-density lipoprotein. Yang CY, et al. Eur J Biochem, 1986 Oct 15. PMID 3095115
  5. LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit. Carlucci A, et al. J Physiol Biochem, 2012 Dec. PMID 22562159

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Local HDAdApoAI vascular gene therapy may promote rapid regression of small-to-moderate-sized atherosclerotic lesions.
    Title: Local Vascular Gene Therapy With Apolipoprotein A-I to Promote Regression of Atherosclerosis.
  2. These differentially expressed proteins associated with key mechanisms involved in atherosclerosis and signaling mechanisms related with vitamin E.
    Title: Identification of differentially expressed proteins in atherosclerotic aorta and effect of vitamin E.
  3. This study showed that apoA-I exerted protective effects against fatty liver disease in rabbits induced by a high-fat diet, possibly through its antioxidant actions.
    Title: Antioxidant effect of apolipoprotein A-I on high-fat diet-induced non-alcoholic fatty liver disease in rabbits.
  4. The molar ratio ApoE/ApoA-I is negatively correlated with the enzyme activity, and positively correlated with increases in the intima-media thickness of common carotid wall and cardiac dysfunction signs.
    Title: LCAT cholesterol esterification is associated with the increase of ApoE/ApoA-I ratio during atherosclerosis progression in rabbit.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables high-density lipoprotein particle receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in lipoprotein metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
apolipoprotein A-I
Names
apo-AI
apoA-I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001101687.1 → NP_001095157.1  apolipoprotein A-I preproprotein

    See identical proteins and their annotated locations for NP_001095157.1

    Status: VALIDATED

    Source sequence(s)
    X06658
    UniProtKB/Swiss-Prot
    P09809
    Related
    ENSOCUP00000009241.2, ENSOCUT00000010731.2
    Conserved Domains (1) summary
    pfam01442
    Location:73 → 240
    Apolipoprotein; Apolipoprotein A1/A4/E domain

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067374.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    113563114..113564779
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P09809.2 GenPept UniProtKB/Swiss-Prot:P09809

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials