EEF1A1 eukaryotic translation elongation factor 1 alpha 1 [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: EEF1A1
Gene description: eukaryotic translation elongation factor 1 alpha 1
See related: Ensembl:ENSOCUG00000008481
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: RABEFLA2
Annotation information: Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 12

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	12	NC_067385.1 (95439640..95442158)

Chromosome 12 - NC_067385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067385.1 Chromosome 12 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data (including data from studies using purified proteins/hepatocyte lysates) suggest eEF1A1/Sgt1a interact as multimer; D2/D3 domains of eEF1A1 and TPR domain of Sgt1 are involved in multimer formation; Sgt1 competes with viral RNA to bind to eEF1A.
Title: Translation elongation factor eEF1A1 is a novel partner of a multifunctional protein Sgt1.
The A,A( *),A' helices region did not interact with actin; however, its removal eliminates the actin bundling activity of eEF1A, probably due to the destruction of a dimeric structure of eEF1A.
Title: Truncation of the A,A(∗),A' helices segment impairs the actin bundling activity of mammalian eEF1A1.

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General gene information

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Markers

GDB:632624 (e-PCR)
- UniSTS:158480

MARC_24185-24186:1034710364:1 (e-PCR)
- UniSTS:268853

EEF1A1 (e-PCR)
- UniSTS:278329

SHGC-178 (e-PCR)
- UniSTS:91474

EEF1A1_3552 (e-PCR)
- UniSTS:462171

ECD01636 (e-PCR)
- UniSTS:282737

D1S3313 (e-PCR)
- UniSTS:63106

PMC26240P1 (e-PCR)
- UniSTS:272315

RH47178 (e-PCR)
- UniSTS:90057

MARC_7355-7356:996687810:1 (e-PCR)
- UniSTS:269771

RH65848 (e-PCR)
- UniSTS:84955

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables translation elongation factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in translation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in translational elongation	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: elongation factor 1-alpha 1

Names: EF-1-alpha-1; EF-Tu; eEF1A-1; elongation factor 1 A-1; elongation factor 1 alpha; elongation factor Tu; eukaryotic elongation factor 1 A-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.