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SLC15A1 solute carrier family 15 member 1 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009186, updated on 10-Oct-2024

Summary

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Gene symbol
SLC15A1
Gene description
solute carrier family 15 member 1
See related
Ensembl:ENSOCUG00000012014
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
PEPT1
Orthologs
human mouse all
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Genomic context

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See SLC15A1 in Genome Data Viewer
Location:
chromosome: 8
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 8 NC_067381.1 (11295008..11337464)

Chromosome 8 - NC_067381.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127492176 Neighboring gene uncharacterized LOC127492000 Neighboring gene serine/threonine kinase 24 Neighboring gene FERM, ARH/RhoGEF and pleckstrin domain protein 1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067381.1 Chromosome 8 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Residues R282 and D341 act as electrostatic gates in the proton-dependent oligopeptide transporter PepT1. Bossi E, et al. J Physiol, 2011 Feb 1. PMID 21115649, Free PMC Article
  2. The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1. Pieri M, et al. Int J Biochem Cell Biol, 2009 Nov. PMID 19389486, Free PMC Article
  3. Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes. Mertl M, et al. Am J Physiol Cell Physiol, 2008 Nov. PMID 18799652
  4. Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1. Pieri M, et al. Int J Biochem Cell Biol, 2008. PMID 18037334, Free PMC Article
  5. Expression cloning of a mammalian proton-coupled oligopeptide transporter. Fei YJ, et al. Nature, 1994 Apr 7. PMID 8139693

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Real time-PCR results indicated that SLC15A1, SLC7A1 and SLC1A1 genes throughout the rabbits' entire development and were expressed in all tested rabbit digestive sites, including the stomach, duodenum, jejunum, ileum, colon and cecum.
    Title: Rabbit SLC15A1, SLC7A1 and SLC1A1 genes are affected by site of digestion, stage of development and dietary protein content.
  2. beta-Klotho participates in the regulation of the peptide transporters PEPT1 and PEPT2.
    Title: β-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2.
  3. Data suggest that USP18 (Ubiquitin-like specific protease 18) sensitive cellular functions include activity of the peptide transporters PEPT1 and PEPT2.
    Title: USP18 Sensitivity of Peptide Transporters PEPT1 and PEPT2.
  4. SPAK is a powerful regulator of peptide transporters PEPT1 and PEPT2
    Title: SPAK dependent regulation of peptide transporters PEPT1 and PEPT2.
  5. Appropriate amino acid substitutions of Arg(282) and Asp(341) change the properties of PepT1 in a way that confirms that these parts of the protein act as an electrostatic gate in the transport process.
    Title: Residues R282 and D341 act as electrostatic gates in the proton-dependent oligopeptide transporter PepT1.
  6. Report PepT1 kinetics in vitro and using computer simulated kinetic models.
    Title: Unified modeling of the mammalian and fish proton-dependent oligopeptide transporter PepT1.
  7. The role of conserved tyrosines in the transmembrane domains (TMDs) of rabbit PepT1 as predicted by hydropathy plots, was investigated.
    Title: The transmembrane tyrosines Y56, Y91 and Y167 play important roles in determining the affinity and transport rate of the rabbit proton-coupled peptide transporter PepT1.
  8. Report substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.
    Title: Substrate-induced changes in the density of peptide transporter PEPT1 expressed in Xenopus oocytes.
  9. Mutation of rabbit PepT1 arginine282 R282E- and R282D-PepT1 showed an increased charge:peptide stoichiometry over the wild-type 1:1 ratio for the neutral dipeptide Gly-l-Gln, measured using two-electrode voltage clamp.
    Title: Site-directed mutagenesis of Arginine282 suggests how protons and peptides are co-transported by rabbit PepT1.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables dipeptide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in oligopeptide transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
solute carrier family 15 member 1
Names
intestinal H(+)/peptide cotransporter
peptide transporter 1
solute carrier family 15 (oligopeptide transporter), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082337.1 → NP_001075806.1  solute carrier family 15 member 1

    See identical proteins and their annotated locations for NP_001075806.1

    Status: PROVISIONAL

    Source sequence(s)
    U06467
    UniProtKB/Swiss-Prot
    P36836
    UniProtKB/TrEMBL
    G1T2G0
    Related
    ENSOCUP00000010337.4, ENSOCUT00000012016.3
    Conserved Domains (2) summary
    TIGR00926
    Location:28 → 669
    2A1704; Peptide:H+ symporter (also transports b-lactam antibiotics, the antitumor agent, bestatin, and various protease inhibitors)
    pfam00854
    Location:81 → 467
    PTR2; POT family

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067381.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    11295008..11337464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051849880.1 → XP_051705840.1  solute carrier family 15 member 1 isoform X3

  2. XM_051849877.1 → XP_051705837.1  solute carrier family 15 member 1 isoform X1

  3. XM_051849879.1 → XP_051705839.1  solute carrier family 15 member 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P36836.1 GenPept UniProtKB/Swiss-Prot:P36836

Gene LinkOut

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Molecular Biology Databases
Research Materials