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MMP3 matrix metallopeptidase 3 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009111, updated on 9-Nov-2023

Summary

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Gene symbol
MMP3
Gene description
matrix metallopeptidase 3
See related
Ensembl:ENSOCUG00000029337
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
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Genomic context

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See MMP3 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 1 NC_067374.1 (127651234..127659767)

Chromosome 1 - NC_067374.1Genomic Context describing neighboring genes Neighboring gene folylpolyglutamate synthase, mitochondrial-like Neighboring gene mediator of RNA polymerase II transcription subunit 8-like Neighboring gene matrix metallopeptidase 12 Neighboring gene matrix metallopeptidase 1 Neighboring gene eukaryotic initiation factor 4A-II-like

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067374.1 Chromosome 1 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning of a complementary DNA for rabbit proactivator. A metalloproteinase that activates synovial cell collagenase, shares homology with stromelysin and transin, and is coordinately regulated with collagenase. Fini ME, et al. Arthritis Rheum, 1987 Nov. PMID 2825726
  2. Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis. Shi J, et al. IUBMB Life, 2016 Apr. PMID 26873249
  3. Chitosan-plasmid DNA nanoparticles encoding small hairpin RNA targeting MMP-3 and -13 to inhibit the expression of dedifferentiation related genes in expanded chondrocytes. Zhao J, et al. J Biomed Mater Res A, 2014 Feb. PMID 23520014
  4. Characterization of total and active matrix metalloproteinases-1, -3, and -13 synthesized and secreted by anterior cruciate ligament fibroblasts in three-dimensional collagen gels. Attia E, et al. Tissue Eng Part A, 2014 Jan. PMID 23879595, Free PMC Article
  5. Effect of ulinastatin on the expression of iNOS, MMP-2, and MMP-3 in degenerated nucleus pulposus cells of rabbits. Hua G, et al. Connect Tissue Res, 2013. PMID 22853554

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Compromised autophagy may be related to the osteoarthritis progression; JNK and p38 MAPKs up-regulate MMP3 and down-regulate autophagy.
    Title: Explore the variation of MMP3, JNK, p38 MAPKs, and autophagy at the early stage of osteoarthritis.
  2. the total content and active forms of matrix metalloproteinases (MMPs)-1, -3, and -13 was measured to assess the potential role of the mechanical environment in regulation of matrix turnover by ligament fibroblasts.
    Title: Characterization of total and active matrix metalloproteinases-1, -3, and -13 synthesized and secreted by anterior cruciate ligament fibroblasts in three-dimensional collagen gels.
  3. chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
    Title: Chitosan-plasmid DNA nanoparticles encoding small hairpin RNA targeting MMP-3 and -13 to inhibit the expression of dedifferentiation related genes in expanded chondrocytes.
  4. Ulinastatin effectively inhibited the increased expression of MMP-2, MMP-3, and iNOS in degenerated NP cells induced by IL-1beta in vitro.
    Title: Effect of ulinastatin on the expression of iNOS, MMP-2, and MMP-3 in degenerated nucleus pulposus cells of rabbits.
  5. Exposure to long periods of light irrespective of its characteristics leads to the increased expression of some matrix metalloprpteases.
    Title: Role of metalloproteases in retinal degeneration induced by violet and blue light.
  6. Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma in atherosclerotic rabbits.
    Title: [Effects of Tongxinluo on MMP-3, 9 and PPARgamma expressions in atherosclerotic rabbits].
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables metalloendopeptidase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in extracellular matrix organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular matrix IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
stromelysin-1
Names
MMP-3
SL-1
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
matrix metalloproteinase 3
transin-1
NP_001075749.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082280.1 → NP_001075749.1  stromelysin-1 preproprotein

    See identical proteins and their annotated locations for NP_001075749.1

    Status: VALIDATED

    Source sequence(s)
    M25664
    UniProtKB/Swiss-Prot
    P28863
    Related
    ENSOCUP00000013084.3, ENSOCUT00000015227.3
    Conserved Domains (4) summary
    cd00094
    Location:291 → 478
    HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
    cd04278
    Location:109 → 265
    ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
    pfam00413
    Location:109 → 265
    Peptidase_M10; Matrixin
    pfam01471
    Location:34 → 88
    PG_binding_1; Putative peptidoglycan binding domain

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067374.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    127651234..127659767
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28863.1 GenPept UniProtKB/Swiss-Prot:P28863

Gene LinkOut

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Molecular Biology Databases
Research Materials