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AKR1C5 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100009071, updated on 6-Jun-2024

Summary

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Gene symbol
AKR1C5
Gene description
aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
AKR1C1
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Genomic context

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See AKR1C5 in Genome Data Viewer
Location:
chromosome: Un
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) Unplaced Scaffold NW_026259195.1 (912718..949827, complement)

NW_026259195.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC127487868 Neighboring gene platelet binding protein GspB Neighboring gene uncharacterized LOC103345162 Neighboring gene putative aldo-keto reductase family 1 member C8 Neighboring gene prostaglandin-E(2) 9-reductase

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_026259195 Unplaced Scaffold Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Loop relaxation, a mechanism that explains the reduced specificity of rabbit 20alpha-hydroxysteroid dehydrogenase, a member of the aldo-keto reductase superfamily. Couture JF, et al. J Mol Biol, 2004 May 21. PMID 15123423
  2. Prostaglandin-E2 9-reductase from corpus luteum of pseudopregnant rabbit is a member of the aldo-keto reductase superfamily featuring 20 alpha-hydroxysteroid dehydrogenase activity. Wintergalen N, et al. Eur J Biochem, 1995 Nov 15. PMID 8529651
  3. Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. Lacy WR, et al. Mol Endocrinol, 1993 Jan. PMID 8446108
  4. Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity. Lacy W, et al. Mol Endocrinol, 1993 Sep. PMID 8247025

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables aldose reductase (NADPH) activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables androsterone dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables bile acid binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ketosteroid monooxygenase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in daunorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in doxorubicin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in progesterone metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in prostaglandin metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
prostaglandin-E(2) 9-reductase
Names
20-alpha-HSD
20-alpha-hydroxysteroid dehydrogenase
NP_001075719.1
XP_051690697.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082250.1 → NP_001075719.1  prostaglandin-E(2) 9-reductase

    See identical proteins and their annotated locations for NP_001075719.1

    Status: PROVISIONAL

    Source sequence(s)
    L17006
    UniProtKB/Swiss-Prot
    P80508
    UniProtKB/TrEMBL
    A0A5F9CBR3
    Conserved Domains (1) summary
    cd19108
    Location:6 → 308
    AKR_AKR1C1-35; AKR1C family of aldo-keto reductase (AKR)

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NW_026259195.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    912718..949827 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051834737.1 → XP_051690697.1  prostaglandin-E(2) 9-reductase isoform X1

    UniProtKB/TrEMBL
    A0A5F9C312
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P80508.1 GenPept UniProtKB/Swiss-Prot:P80508

Gene LinkOut

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