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ARG2 arginase 2 [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008967, updated on 8-Mar-2024

Summary

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Gene symbol
ARG2
Gene description
arginase 2
See related
Ensembl:ENSOCUG00000000584
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See ARG2 in Genome Data Viewer
Location:
chromosome: 20
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 20 NC_067393.1 (4314296..4350136, complement)

Chromosome 20 - NC_067393.1Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 12 Neighboring gene uncharacterized LOC127484650 Neighboring gene retinol dehydrogenase 11 Neighboring gene vesicle transport through interaction with t-SNAREs 1B Neighboring gene pleckstrin homology, MyTH4 and FERM domain containing H1 Neighboring gene phosphatidylinositol glycan anchor biosynthesis class H Neighboring gene transmembrane protein 229B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067393.1 Chromosome 20 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation. Heusch P, et al. Am J Physiol Heart Circ Physiol, 2010 Aug. PMID 20511413
  2. Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction. Figueroa H, et al. Prenat Diagn, 2016 Jul. PMID 27109011

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kidneys from circulation-restricted fetuses showed arginase-2 protein induction.
    Title: Nitric oxide synthase and changes in oxidative stress levels in embryonic kidney observed in a rabbit model of intrauterine growth restriction.
  2. In heart failure, increased iNOS and arginase II expression results in unchanged NO species and protein S-nitrosylation; with substrate limitation, uncoupled iNOS produces superoxide anions and contributes to contractile dysfunction.
    Title: Increased inducible nitric oxide synthase and arginase II expression in heart failure: no net nitrite/nitrate production and protein S-nitrosylation.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables arginase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables manganese ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in arginine catabolic process to ornithine IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
arginase-2, mitochondrial
Names
arginase II
arginase, type II
mitochondrial arginase 2
mitochondrial arginase type II
type II arginase
NP_001075650.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082181.1 → NP_001075650.1  arginase-2, mitochondrial precursor

    See identical proteins and their annotated locations for NP_001075650.1

    Status: PROVISIONAL

    Source sequence(s)
    AY864853
    UniProtKB/Swiss-Prot
    Q4VK78
    UniProtKB/TrEMBL
    G1SDL7
    Related
    ENSOCUP00000000507.2, ENSOCUT00000000584.2
    Conserved Domains (1) summary
    cd09989
    Location:26 → 321
    Arginase; Arginase family

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067393.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    4314296..4350136 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4VK78.1 GenPept UniProtKB/Swiss-Prot:Q4VK78

Gene LinkOut

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