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PKD2 polycystin 2, transient receptor potential cation channel [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008872, updated on 8-Mar-2024

Summary

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Gene symbol
PKD2
Gene description
polycystin 2, transient receptor potential cation channel
See related
Ensembl:ENSOCUG00000002396
Gene type
protein coding
RefSeq status
MODEL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as
PKD2L1
Orthologs
human mouse all
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Genomic context

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See PKD2 in Genome Data Viewer
Location:
chromosome: 15
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 15 NC_067388.1 (58994052..59050959, complement)

Chromosome 15 - NC_067388.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC103350759 Neighboring gene ATP-binding cassette sub-family G member 2 Neighboring gene U6 spliceosomal RNA Neighboring gene broad substrate specificity ATP-binding cassette transporter ABCG2-like Neighboring gene uncharacterized LOC127483174 Neighboring gene secreted phosphoprotein 1 Neighboring gene uncharacterized LOC127483175 Neighboring gene uncharacterized LOC127483361 Neighboring gene matrix extracellular phosphoglycoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067388.1 Chromosome 15 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lack of a laterality phenotype in Pkd1 knock-out embryos correlates with absence of polycystin-1 in nodal cilia. Karcher C, et al. Differentiation, 2005 Oct. PMID 16316413
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables muscle alpha-actinin binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated calcium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables voltage-gated sodium channel activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in detection of mechanical stimulus IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in release of sequestered calcium ion into cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
polycystin-2
Names
polycystic kidney disease 2 (autosomal dominant)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067388.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    58994052..59050959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_002717010.4 → XP_002717056.1  polycystin-2

    UniProtKB/TrEMBL
    G1SHG5
    Related
    ENSOCUP00000002070.3
    Conserved Domains (2) summary
    pfam08016
    Location:269 → 689
    PKD_channel; Polycystin cation channel
    cl08302
    Location:734 → 780
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
Nucleotide Protein
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