LEP leptin [Oryctolagus cuniculus (rabbit)] - Gene

Summary

Gene symbol: LEP
Gene description: leptin
See related: Ensembl:ENSOCUG00000010189
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Oryctolagus cuniculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Also known as: OB
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_02	current	UM_NZW_1.0 (GCF_009806435.1)	7	NC_067380.1 (157446709..157460792)

Chromosome 7 - NC_067380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_067380.1 Chromosome 7 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study suggests that increased CSF leptin, likely from blood-brain barrier breakdown, combined with elevated serum GH and IGF-1 after traumatic brain injury, leads to accelerated fracture healing
Title: Leptin's effect on accelerated fracture healing after traumatic brain injury.
We conclude that offspring from mothers consuming a high fat diet exhibit an adverse cardiovascular profile in adulthood because of altered central hypothalamic sensitivity to leptin and ghrelin.
Title: Exposure to a high-fat diet during development alters leptin and ghrelin sensitivity and elevates renal sympathetic nerve activity and arterial pressure in rabbits.
Niacin Reduces serum level and adipose mRNA expression of leptin and up-regulates PPARgamma and CD36 mRNA expression in hypercholesterolemic rabbits.
Title: Effect of niacin on adipocyte leptin in hypercholesterolemic rabbits.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed
enables peptide hormone receptor binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activation of protein kinase C activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in energy reserve metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of appetite by leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of TOR signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of p38MAPK cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info	PubMed
involved_in response to insulin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in tyrosine phosphorylation of STAT protein	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: leptin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.