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LIPC lipase C, hepatic type [ Oryctolagus cuniculus (rabbit) ]

Gene ID: 100008678, updated on 10-Oct-2024

Summary

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Gene symbol
LIPC
Gene description
lipase C, hepatic type
See related
Ensembl:ENSOCUG00000001647
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Oryctolagus cuniculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Lagomorpha; Leporidae; Oryctolagus
Orthologs
human mouse all
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Genomic context

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See LIPC in Genome Data Viewer
Location:
chromosome: 17
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_02 current UM_NZW_1.0 (GCF_009806435.1) 17 NC_067390.1 (14789106..14947770, complement)

Chromosome 17 - NC_067390.1Genomic Context describing neighboring genes Neighboring gene SAFB like transcription modulator Neighboring gene MINDY lysine 48 deubiquitinase 2 Neighboring gene ADAM metallopeptidase domain 10 Neighboring gene uncharacterized LOC127484089 Neighboring gene uncharacterized LOC103351099 Neighboring gene aquaporin 9 Neighboring gene aldehyde dehydrogenase 1 family member A2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_067390.1 Chromosome 17 Reference UM_NZW_1.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rabbit hepatic lipase cDNA sequence: low activity is associated with low messenger RNA levels. Warren RJ, et al. J Lipid Res, 1991 Aug. PMID 1770315
  2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables apolipoprotein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables triacylglycerol lipase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
hepatic triacylglycerol lipase
Names
HL
hepatic lipase
lipase member C
lipase, hepatic
lysophospholipase
phospholipase A1
NP_001075501.1
XP_051677661.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082032.1 → NP_001075501.1  hepatic triacylglycerol lipase precursor

    See identical proteins and their annotated locations for NP_001075501.1

    Status: PROVISIONAL

    Source sequence(s)
    AF041202
    UniProtKB/Swiss-Prot
    O46559
    UniProtKB/TrEMBL
    G1SFU2
    Related
    ENSOCUP00000001411.3, ENSOCUT00000001646.4
    Conserved Domains (3) summary
    cd00707
    Location:47 → 332
    Pancreat_lipase_like; Pancreatic lipase-like enzymes. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the ...
    cd01758
    Location:352 → 487
    PLAT_LPL; PLAT/ LH2 domain present in lipoprotein lipase (LPL). LPL is a key enzyme in catabolism of plasma lipoprotein triglycerides (TGs) and has therefeore has a profound influence on triglyceride and high-density lipoprotein (HDL) cholesterol levels in the ...
    pfam00151
    Location:18 → 349
    Lipase; Lipase

RefSeqs of Annotated Genomes: GCF_009806435.1-RS_2023_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UM_NZW_1.0 Primary Assembly

Genomic

  1. NC_067390.1 Reference UM_NZW_1.0 Primary Assembly

    Range
    14789106..14947770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_051821701.1 → XP_051677661.1  hepatic triacylglycerol lipase isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O46559.1 GenPept UniProtKB/Swiss-Prot:O46559

Gene LinkOut

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