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hbl1 hexose-binding lectin 1 [ Danio rerio (zebrafish) ]

Gene ID: 100007982, updated on 2-Nov-2024

Summary

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Official Symbol
hbl1provided by ZNC
Official Full Name
hexose-binding lectin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-070912-285
See related
Ensembl:ENSDARG00000068221 AllianceGenome:ZFIN:ZDB-GENE-070912-285
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
mbl; si:ch211-284o19.2
Summary
Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); bacterial infectious disease (multiple); fungal infectious disease (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human MBL2 (mannose binding lectin 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hbl1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (37894849..37897077, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (37912391..37914536, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene mannose binding lectin 2 Neighboring gene hexose-binding lectin 2 Neighboring gene telomerase-associated protein 1 Neighboring gene complement C1q-like protein 3 Neighboring gene cerebellin 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Characterization of a mannose-binding lectin from channel catfish (Ictalurus punctatus). Zhang H, et al. Res Vet Sci, 2012 Jun. PMID 21524427
  2. Mannose binding lectin (MBL) copy number polymorphism in Zebrafish (D. rerio) and identification of haplotypes resistant to L. anguillarum. Jackson AN, et al. Immunogenetics, 2007 Nov. PMID 17943278
  3. Lectin pathway of bony fish complement: identification of two homologs of the mannose-binding lectin associated with MASP2 in the common carp (Cyprinus carpio). Nakao M, et al. J Immunol, 2006 Oct 15. PMID 17015733
  4. Labeled microRNA pull-down assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs. Hsu RJ, et al. Nucleic Acids Res, 2009 Jun. PMID 19420057, Free PMC Article
  5. Transcriptomic characterization of adult zebrafish infected with Streptococcus agalactiae. Wu XM, et al. Fish Shellfish Immunol, 2019 Nov. PMID 31533079

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mannose-binding protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    37894849..37897077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009298673.4 → XP_009296948.2  mannose-binding protein C isoform X1

    UniProtKB/TrEMBL
    A0A8M3AQC7, E9QHK9
    Related
    ENSDARP00000110218.2, ENSDART00000129852.3
    Conserved Domains (1) summary
    cl02432
    Location:178 → 294
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

  2. XM_001341879.7 → XP_001341915.2  mannose-binding protein C isoform X2

    UniProtKB/TrEMBL
    A0A8M9PXC5, E9QHK9
    Conserved Domains (1) summary
    cl02432
    Location:177 → 293
    CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394505.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    85841..94240 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068218031.1 → XP_068074132.1  mannose-binding protein C isoform X3

  2. XM_068218032.1 → XP_068074133.1  mannose-binding protein C isoform X5

  3. XM_021471256.2 → XP_021326931.2  mannose-binding protein C isoform X4

  4. XM_021471255.2 → XP_021326930.2  mannose-binding protein C isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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