gphnb gephyrin b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: gphnbprovided by ZNC
Official Full Name: gephyrin bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-070705-4
See related: Ensembl:ENSDARG00000100851 AllianceGenome:ZFIN:ZDB-GENE-070705-4
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: gphn2; fj59a01; wu:fj59a01
Summary: Predicted to enable molybdopterin molybdotransferase activity. Acts upstream of or within glycine receptor clustering. Predicted to be active in several cellular components, including dendrite; postsynaptic membrane; and postsynaptic specialization. Is expressed in head; rhombomere; spinal cord; and spinal cord interneuron. Human ortholog(s) of this gene implicated in inherited metabolic disorder and molybdenum cofactor deficiency type C. Orthologous to human GPHN (gephyrin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 20

Exon count:: 27

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	20	NC_007131.7 (50852235..50999403)
105	previous assembly	GRCz10 (GCF_000002035.5)	20	NC_007131.6 (51034311..51185031)

Chromosome 20 - NC_007131.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molybdopterin adenylyltransferase activity	IEA Inferred from Electronic Annotation more info
enables molybdopterin molybdotransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables molybdopterin molybdotransferase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Mo-molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in establishment of synaptic specificity at neuromuscular junction	IBA Inferred from Biological aspect of Ancestor more info
involved_in gamma-aminobutyric acid receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
involved_in glycine receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within glycine receptor clustering	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within molybdopterin cofactor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in postsynaptic neurotransmitter receptor diffusion trapping	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IGI Inferred from Genetic Interaction more info	PubMed
is_active_in postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic specialization	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: gephyrin b

Names: gephyrin2

NP_001165871.1

EC 2.10.1.1

XP_021324010.1

EC 2.10.1.1

XP_021324011.1

EC 2.10.1.1

XP_021324013.1

EC 2.10.1.1

XP_021324014.1

EC 2.10.1.1

XP_021324015.1

EC 2.10.1.1

XP_021324016.1

EC 2.10.1.1

XP_021324017.1

EC 2.10.1.1

XP_021324018.1

EC 2.10.1.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001172400.1 → NP_001165871.1 gephyrin b

See identical proteins and their annotated locations for NP_001165871.1

Status: PROVISIONAL

Source sequence(s)

AB546101

UniProtKB/TrEMBL

A0A0R4IL13, A0A8M1NVY3, D3KYL2

Related

ENSDARP00000134783.2, ENSDART00000167517.2

Conserved Domains (3) summary

COG0303
Location:381 → 790

MoeA; Molybdopterin biosynthesis enzyme [Coenzyme transport and metabolism]

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:387 → 793

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007131.7 Reference GRCz11 Primary Assembly

Range

50852235..50999403

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021468336.1 → XP_021324011.1 gephyrin b isoform X2

UniProtKB/TrEMBL

A0A8M9PP37

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:385 → 794

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468335.1 → XP_021324010.1 gephyrin b isoform X1

UniProtKB/TrEMBL

A0A8M9PSF7

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:387 → 796

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468338.1 → XP_021324013.1 gephyrin b isoform X3

UniProtKB/TrEMBL

A0A8M9PBI8

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:373 → 782

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468339.1 → XP_021324014.1 gephyrin b isoform X4

UniProtKB/TrEMBL

A0A8M9PH34

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:371 → 780

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468340.1 → XP_021324015.1 gephyrin b isoform X5

UniProtKB/TrEMBL

A0A8M9PSG2

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:327 → 736

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468341.1 → XP_021324016.1 gephyrin b isoform X6

UniProtKB/TrEMBL

A0A0G2KS66, A0A8M9PP41, D3KYL1

Related

ENSDARP00000135251.2, ENSDART00000168396.2

Conserved Domains (2) summary

cd00886
Location:15 → 169

MogA_MoaB; MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea, ...

cd00887
Location:327 → 733

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468342.1 → XP_021324017.1 gephyrin b isoform X7

UniProtKB/TrEMBL

A0A8M9P2E8

Conserved Domains (1) summary

cd00887
Location:244 → 653

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
XM_021468343.1 → XP_021324018.1 gephyrin b isoform X8

UniProtKB/TrEMBL

A0A8M9PBJ3

Related

ENSDARP00000138940.1, ENSDART00000170854.2

Conserved Domains (1) summary

cd00887
Location:101 → 510

MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...