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vwde von Willebrand factor D and EGF domains [ Danio rerio (zebrafish) ]

Gene ID: 100006681, updated on 18-Sep-2024

Summary

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Official Symbol
vwdeprovided by ZNC
Official Full Name
von Willebrand factor D and EGF domainsprovided by ZNC
Primary source
ZFIN:ZDB-GENE-131121-540
See related
Ensembl:ENSDARG00000101697 AllianceGenome:ZFIN:ZDB-GENE-131121-540
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
vwdel; si:dkey-30e9.7
Summary
Predicted to enable calcium ion binding activity. Orthologous to human VWDE (von Willebrand factor D and EGF domains). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See vwde in Genome Data Viewer
Location:
chromosome: 15
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (33994569..34059289, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34136602..34198840, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 106Ba Neighboring gene Schwann cell-specific EGF-like repeat autocrine factor Neighboring gene si:dkey-30e9.6 Neighboring gene ADP-ribosylation factor-like 4aa Neighboring gene ETS variant transcription factor 1 Neighboring gene diacylglycerol kinase, beta

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Identification of the neural crest-specific enhancer of Seraf gene in avian peripheral nervous system development. Suzuki T, et al. Biochem Biophys Res Commun, 2015 Nov 27. PMID 26494297
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular region IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
von Willebrand factor D and EGF domain-containing protein
Names
zmp:0000001015

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    33994569..34059289 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068213774.1 → XP_068069875.1  von Willebrand factor D and EGF domain-containing protein isoform X2

  2. XM_001345324.8 → XP_001345360.4  von Willebrand factor D and EGF domain-containing protein isoform X1

    UniProtKB/TrEMBL
    A0A0R4IWA2, A0A8M1PVC7
    Related
    ENSDARP00000140652.1, ENSDART00000170130.2
    Conserved Domains (3) summary
    smart00179
    Location:1190 → 1229
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:1153 → 1187
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cl02516
    Location:422 → 580
    VWD; von Willebrand factor type D domain
Nucleotide Protein Strain
Heading Accession and Version

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