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sh3gl1a SH3-domain GRB2-like 1a [ Danio rerio (zebrafish) ]

Gene ID: 100005753, updated on 14-Nov-2024

Summary

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Official Symbol
sh3gl1aprovided by ZNC
Official Full Name
SH3-domain GRB2-like 1aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-4524
See related
Ensembl:ENSDARG00000067958 AllianceGenome:ZFIN:ZDB-GENE-030131-4524
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
sh3gl1b; zgc:56637; wu:fd12b05; wu:fy33c10
Summary
Predicted to be involved in synaptic vesicle uncoating. Predicted to be located in cell projection; early endosome membrane; and podosome. Predicted to be active in cytoplasm; glutamatergic synapse; and presynapse. Is expressed in several structures, including EVL; digestive system; epidermis; hatching gland; and periderm. Human ortholog(s) of this gene implicated in acute myeloid leukemia and high grade glioma. Orthologous to human SH3GL1 (SH3 domain containing GRB2 like 1, endophilin A2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See sh3gl1a in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (49457638..49511458)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (49723401..49777228)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6Ba Neighboring gene RAR-related orphan receptor C b Neighboring gene si:ch211-209f23.3 Neighboring gene signal transducing adaptor family member 2a Neighboring gene semaphorin 4e

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Essential role of SH3-domain GRB2-like 3 for vascular lumen maintenance in zebrafish. Zhao Y, et al. Arterioscler Thromb Vasc Biol, 2013 Jun. PMID 23539215
  2. eena Promotes myeloid proliferation through stimulating ERK1/2 phosphorylation in zebrafish. Le HY, et al. J Biol Chem, 2008 Jun 20. PMID 18413315
  3. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
  4. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC56637

Gene Ontology Provided by ZFIN

Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in podosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SH3-domain GRB2-like 1a
Names
SH3-domain GRB2-like 1b
eenb

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001105606.1 → NP_001099076.1  SH3-domain GRB2-like 1a isoform 1

    See identical proteins and their annotated locations for NP_001099076.1

    Status: PROVISIONAL

    Source sequence(s)
    BC153638
    UniProtKB/TrEMBL
    A8E5L6, F6NXU5, Q1MT71
    Related
    ENSDARP00000110333.2, ENSDART00000129967.3
    Conserved Domains (2) summary
    cd07592
    Location:25 → 247
    BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
    cd11803
    Location:307 → 361
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

  2. NM_200301.1 → NP_956595.1  SH3-domain GRB2-like 1a isoform 2

    See identical proteins and their annotated locations for NP_956595.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049513
    UniProtKB/TrEMBL
    Q7ZWA0
    Conserved Domains (2) summary
    cd07592
    Location:25 → 247
    BAR_Endophilin_A; The Bin/Amphiphysin/Rvs (BAR) domain of Endophilin-A
    cd11803
    Location:307 → 361
    SH3_Endophilin_A; Src homology 3 domain of Endophilin-A

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    49457638..49511458
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068222410.1 → XP_068078511.1  SH3-domain GRB2-like 1a isoform X1

    Related
    ENSDARP00000151484.1, ENSDART00000185470.1
Nucleotide Protein
Heading Accession and Version

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