stac SH3 and cysteine rich domain [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: stacprovided by ZNC
Official Full Name: SH3 and cysteine rich domainprovided by ZNC
Primary source: ZFIN:ZDB-GENE-131121-459
See related: Ensembl:ENSDARG00000074004 AllianceGenome:ZFIN:ZDB-GENE-131121-459
Gene type: protein coding
RefSeq status: MODEL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: si:dkey-74h17.2
Summary: Predicted to enable transmembrane transporter binding activity. Predicted to be involved in positive regulation of protein localization to plasma membrane; positive regulation of voltage-gated calcium channel activity; and skeletal muscle contraction. Predicted to act upstream of or within intracellular signal transduction. Predicted to be located in sarcolemma. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human STAC (SH3 and cysteine rich domain). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (24747229..24787808)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (24728790..24769406)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transmembrane transporter binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in positive regulation of protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in sarcolemma	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: SH3 and cysteine-rich domain-containing protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

24747229..24787808

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001344434.8 → XP_001344470.4 SH3 and cysteine-rich domain-containing protein isoform X1

UniProtKB/TrEMBL

A0A8M1Q7W1

Related

ENSDARP00000129479.1, ENSDART00000154623.3

Conserved Domains (4) summary

cd11833
Location:325 → 377

SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins

cd00029
Location:133 → 189

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam16664
Location:201 → 318

STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

cl17036
Location:384 → 434

SH3; Src Homology 3 domain superfamily
XM_009293069.4 → XP_009291344.1 SH3 and cysteine-rich domain-containing protein isoform X2

UniProtKB/TrEMBL

A0A8M3AJV3

Conserved Domains (4) summary

cd11833
Location:315 → 367

SH3_Stac_1; First C-terminal Src homology 3 domain of SH3 and cysteine-rich domain-containing (Stac) proteins

cd00029
Location:133 → 179

C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

pfam16664
Location:191 → 308

STAC2_u1; Unstructured on SH3 and cysteine-rich domain-containing protein 2

cl17036
Location:374 → 424

SH3; Src Homology 3 domain superfamily