dguok deoxyguanosine kinase [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dguokprovided by ZNC
Official Full Name: deoxyguanosine kinaseprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040625-14
See related: Ensembl:ENSDARG00000075395 AllianceGenome:ZFIN:ZDB-GENE-040625-14
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:86625
Summary: Predicted to enable deoxyguanosine kinase activity. Predicted to act upstream of or within nucleobase-containing compound metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in autosomal recessive progressive external ophthalmoplegia with mitochondrial DNA deletions 4; mitochondrial DNA depletion syndrome 3; mitochondrial metabolism disease; and portal hypertension. Orthologous to human DGUOK (deoxyguanosine kinase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (69702602..69707787, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (68930050..68935235, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc37g07.x1 (e-PCR)
- UniSTS:193715

fe50h07.x1 (e-PCR)
- UniSTS:196594

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables deoxyguanosine kinase activity	IEA Inferred from Electronic Annotation more info
enables deoxynucleoside kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxynucleoside kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within nucleobase-containing compound metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: deoxyguanosine kinase, mitochondrial

NP_001093561.1

EC 2.7.1.113

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001100091.1 → NP_001093561.1 deoxyguanosine kinase, mitochondrial

Status: PROVISIONAL

Source sequence(s)

CR847941

UniProtKB/TrEMBL

A0A8M1NDS2, A5WUY2

Related

ENSDARP00000103858.3, ENSDART00000108820.5

Conserved Domains (1) summary

pfam01712
Location:32 → 267

dNK; Deoxynucleoside kinase