rpe65b retinoid isomerohydrolase RPE65 b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: rpe65bprovided by ZNC
Official Full Name: retinoid isomerohydrolase RPE65 bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050410-16
See related: Ensembl:ENSDARG00000094752 AllianceGenome:ZFIN:ZDB-GENE-050410-16
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: rpepb; RPE56b; wu:fc74c09; zgc:110538; si:ch211-198n5.5
Summary: Predicted to enable all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity; beta-carotene 15,15'-dioxygenase activity; and retinol isomerase activity. Predicted to be involved in retinal metabolic process and zeaxanthin biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in ectoderm; mandibular arch skeleton; nervous system; neural crest cell; and pectoral fin. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 2; retinitis pigmentosa; retinitis pigmentosa 20; and retinitis pigmentosa 87. Orthologous to human RPE65 (retinoid isomerohydrolase RPE65). [provided by Alliance of Genome Resources, Oct 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (16688366..16697912, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (16652654..16662200, complement)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Markers

fc74c09.x1 (e-PCR)
- UniSTS:188246

G44897 (e-PCR)
- UniSTS:105699

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity	IBA Inferred from Biological aspect of Ancestor more info
enables beta-carotene 15,15'-dioxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IEA Inferred from Electronic Annotation more info
enables retinol isomerase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in retinal metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in zeaxanthin biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: all-trans-retinyl ester 13-cis isomerohydrolase

Names: 13cIMH; lutein isomerase; meso-zeaxanthin isomerase; retinal pigment epithelium 65b; retinal pigment epithelium-specific 65 kDa protein homolog B; retinal pigment epithelium-specific protein 65b; retinal pigment epithelium-specific protein b

NP_001082902.2

EC 3.1.1.90

EC 5.3.3.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.