sufu suppressor of fused homolog (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: sufuprovided by ZNC
Official Full Name: suppressor of fused homolog (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6223
See related: Ensembl:ENSDARG00000056801 AllianceGenome:ZFIN:ZDB-GENE-030131-6223
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dre; Su(fu); fi39e05; sb:eu762; wu:fi39e05
Summary: Enables zinc ion binding activity. Acts upstream of or within several processes, including lens development in camera-type eye; negative regulation of smoothened signaling pathway; and smoothened signaling pathway. Part of Hedgehog signaling complex. Human ortholog(s) of this gene implicated in Joubert syndrome 32; familial meningioma; medulloblastoma; and nevoid basal cell carcinoma syndrome 2. Orthologous to human SUFU (SUFU negative regulator of hedgehog signaling). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	13	NC_007124.7 (11829070..11869803)
105	previous assembly	GRCz10 (GCF_000002035.5)	13	NC_007124.6 (11696563..11737328)

Chromosome 13 - NC_007124.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Through regulation of su(fu), miR-214 enables precise specification of muscle cell types by sharpening cellular responses to Hedgehog.
Title: Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AW171349 (e-PCR)
- UniSTS:205827

fi39e05.x1 (e-PCR)
- UniSTS:197445

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within fin development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lens development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within smoothened signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Hedgehog signaling complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: suppressor of fused homolog

Names: dreumes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201309.1 → NP_958466.1 suppressor of fused homolog

See identical proteins and their annotated locations for NP_958466.1

Status: PROVISIONAL

Source sequence(s)

BC045348

UniProtKB/TrEMBL

Q7ZVZ9

Related

ENSDARP00000133214.1, ENSDART00000079356.8

Conserved Domains (2) summary

pfam05076
Location:58 → 230

SUFU; Suppressor of fused protein (SUFU)

pfam12470
Location:244 → 474

SUFU_C; Suppressor of Fused Gli/Ci N terminal binding domain