ngb neuroglobin [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ngbprovided by ZNC
Official Full Name: neuroglobinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-011102-1
See related: Ensembl:ENSDARG00000053475 AllianceGenome:ZFIN:ZDB-GENE-011102-1
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Summary: Enables nitrite reductase activity and oxygen binding activity. Acts upstream of or within response to hypoxia. Predicted to be located in cytosol and mitochondrial matrix. Is expressed in blood; brain; and eye. Orthologous to human NGB (neuroglobin). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 17

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	17	NC_007128.7 (44961948..44968146, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	17	NC_007128.6 (44848187..44854346, complement)

Chromosome 17 - NC_007128.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The zebrafish Neuroglobin can catalyze the reduction of nitrite to nitric oxide with a broad range of reaction rate constants.
Title: Characterization of zebrafish neuroglobin and cytoglobins 1 and 2: Zebrafish cytoglobins provide insights into the transition from six-coordinate to five-coordinate globins.
Data show that the neuroglobin (Ngb) protein was upregulated in the amacrine cells after optic nerve injury.
Title: A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina.
Chimeric Myoglobin has a cell-membrane-penetrating activity similar to zebrafish Ngb.
Title: Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity.
both zebrafish and chimeric ZHHH Ngb can penetrate cell membranes in the absence of Chariot
Title: Zebrafish neuroglobin is a cell-membrane-penetrating globin.
Neuroglobin appears to be associated with mitochondria-rich cell types and thus oxygen consumption rates, suggesting a myoglobin-like function of this protein in facilitated oxygen diffusion
Title: Zebrafish reveals different and conserved features of vertebrate neuroglobin gene structure, expression pattern, and ligand binding.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables GDP-dissociation inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nitrite reductase activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on other nitrogenous compounds as donors	IEA Inferred from Electronic Annotation more info
enables oxygen binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen binding	IDA Inferred from Direct Assay more info	PubMed
enables oxygen binding	IEA Inferred from Electronic Annotation more info
enables oxygen carrier activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxygen carrier activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to hypoxia	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxygen transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oxygen transport	IEA Inferred from Electronic Annotation more info
involved_in response to hypoxia	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to hypoxia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: neuroglobin

Names: nitrite reductase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131853.1 → NP_571928.1 neuroglobin

See identical proteins and their annotated locations for NP_571928.1

Status: PROVISIONAL

Source sequence(s)

AJ315610

UniProtKB/Swiss-Prot

B0R176, Q90YJ2

UniProtKB/TrEMBL

A0A8M9P002

Related

ENSDARP00000069992.4, ENSDART00000075510.6

Conserved Domains (1) summary

cl21461
Location:4 → 150

Globin_like; Globin-like proteins

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007128.7 Reference GRCz11 Primary Assembly

Range

44961948..44968146 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021467082.2 → XP_021322757.1 neuroglobin isoform X1

UniProtKB/Swiss-Prot

B0R176, Q90YJ2

UniProtKB/TrEMBL

A0A8M9P002

Related

ENSDARP00000137134.2, ENSDART00000165850.2

Conserved Domains (1) summary

cl21461
Location:4 → 150

Globin_like; Globin-like proteins