GEO DataSets

Analysis of pulmonary CDC11c+ cells from 6-8 week and 10-13 month old C57BL/6 animals. CDC11c+ cells are key modulators of the immune response in the lung. Results provide insight into molecular mechanisms underlying the decline in immune function associated with aging.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL6885

Series:

GSE71868

8 Samples

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Analysis of myogenic stem cells called satellite cells (mSCs) FACS-sorted from the trunk of Pax3GFP/+ mice at postnatal days 1, 12, and 28, a period when most mSCs are in proliferation and quiescence states. Results provide insight into molecular basis of early postnatal skeletal muscle development.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 3 age, 2 tissue sets

Platform:

GPL1261

Series:

GSE65927

11 Samples

Download data: CEL

Analysis of cochlea from 4 wk old DBA/2J males (a model of progressive hearing loss) injected for 8 wks with a combination of epigenetic modifiers l-methionine and valproic acid. Results provide insight into the effect of epigenetic modifications on the molecular mechanisms underlying hearing loss.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 3 protocol sets

Platform:

GPL1261

Series:

GSE62173

16 Samples

Download data: CEL

Analysis of hepatoblasts, immature hepatocytes and hepatocytes from livers at different developmental timepoints (embryonic day 14, embryonic day 18, post-natal day 5, post-natal day 56). Results provide insight into molecular mechanisms underlying normal liver development.

Organism:

Mus musculus

Type:

Expression profiling by array, log2 ratio, 4 age, 3 cell type, 2 development stage sets

Platform:

GPL7202

Series:

GSE65063

11 Samples

Download data: TXT

Analysis of lung from cigarette smoke (CS)-treated C57BL/6N females at 4 and 6 months of age. Tobacco smoking is a major cause of chronic obstructive pulmonary disease (COPD). Results provide insight into the molecular mechanisms underlying cigarette smoke-induced COPD.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 stress sets

Platform:

GPL6885

Series:

GSE52509

12 Samples

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Analysis of corneal endothelium from pediatric (4-11 years old) and adult (53-70 years old) donor corneas. Results provide insight into differential molecular expression between pediatric and adult corneal endothelial cells.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 age sets

Platform:

GPL11532

Series:

GSE58315

9 Samples

Download data: CEL

Analysis of kidney tumors from Lin28a transgenics at 5 weeks and 4 months of age. Overexpression of heterochronic regulator Lin28 during kidney development promotes Wilms tumor formation. Results provide insight into the role of Lin28 in Wilms tumor formation.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 disease state sets

Platform:

GPL6885

Series:

GSE56323

8 Samples

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Comparison of dendritic cells (DCs) from young (20 to 27 years) and aged (77 to 87 years) donors. DCs are antigen-presenting cells important in initiating and regulating innate and adaptive immune responses. Results provide insight into the molecular basis of the decline in DC function with age.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL571

Series:

GSE58015

9 Samples

Download data: CEL

Analysis of FACS-sorted CD45-Ter119-Sca-1-CD29+Cxcr4+ skeletal muscle precursor (SMP) cells from young, middle-aged, and old C57BL/6 males. Results provide insight into the molecular mechanisms underlying age-related skeletal muscle and stem cell dysfunction.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL1261

Series:

GSE50821

14 Samples

Download data: CEL

Analysis of postmortem neuropathologically normal brain samples from the frontal cortical regions of young, middle aged, normal aged and extremely aged adults. Results provide insight into molecular mechanisms of aging in frontal cortical regions of the brain.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 age, 2 gender sets

Platform:

GPL570

Series:

GSE53890

41 Samples

Download data: CEL

Analysis of adult alveolar type (AT) 2 and E18 bipotent progenitor (BP) lung cells. During development, AT1 and AT2 cells arise from a BP; after birth, new AT1 cells derive from rare, long-lived, self-renewing mature AT2 cells. Results provide insight into the molecular basis of AT2 self-renewal.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age, 2 cell type sets

Platform:

GPL1261

Series:

GSE49346

6 Samples

Download data: CEL, CHP

Analysis of distal trachea and carina region of young (2 month) and old (14 month) C57Bl/6 females. Aging lungs are associated with a variety of structural and pathologic changes. Results provide insight into molecular mechanisms underlying age-related changes in respiratory epithelium.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 age sets

Platform:

GPL1261

Series:

GSE55162

8 Samples

Download data: CEL

Analysis of brain from young (7.5-8.5 months) and old (31-36 months) wildtype males and females. Brains are sexually dimorphic in adults. Results provide insight into the molecular mechanisms associated with brain aging across gender.

Organism:

Danio rerio

Type:

Expression profiling by array, transformed count, 2 age, 2 gender sets

Platform:

GPL1319

Series:

GSE53430

12 Samples

Download data: CEL

Analysis of tendon cells isolated by FACS from forelimbs of embryonic day 11.5, E12.5 and E14.5 scleraxis (Scx)-GFP embryos. Basic helix-loop-helix transcription factor Scx is a specific tendon and ligament marker. Results provide insight into molecular pathways involved in tendon development.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age sets

Platform:

GPL1261

Series:

GSE54207

9 Samples

Download data: CEL, CHP

Analysis of bone marrow hematopoietic cells in chronic myeloid leukemia (CML) patients one month after imatinib mesylate (IM) therapy. CML is caused by expression of the BCR/ABL fusion oncogene. Results provide insight into the molecular consequences of IM blockade of oncoprotein Bcr-Abl in CML.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 10 age, 10 gender, 10 individual, 3 protocol sets

Platform:

GPL570

Series:

GSE33075

27 Samples

Download data: CEL

Analysis of liver from IQ-motif containing GTPase-activating protein 2 (IQGAP2) KOs at 6- and 24-months of age. IQGAP2 is a member of a multidomain scaffolding protein family that also includes IQGAP1 and IQGAP3. Results provide insight into a potential tumor suppressive role for IQGAP2 in liver.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE46646

12 Samples

Download data: CEL

Analysis of muscle from aged animals with muscle-specific Pgc-1α depletion. PGC-1alpha is a transcriptional coactivator of the mitochondrial gene program. Results provide insight into the role of Pgc-1α in the glucose intolerance and chronic systemic inflammation associated with aging.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE52550

12 Samples

Download data: CEL

Analysis of peripheral blood from asthmatic and non-asthmatic children (ages 9 to 13), participants of the MICA study conducted by the EPA from 11/2006 to 01/2007 in Detroit, MI. These results, together with clinical biomarker measurements, may help to differentiate asthmatics from non-asthmatics.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 5 age, 3 disease state, 2 gender sets

Platform:

GPL570

Series:

GSE35571

131 Samples

Download data: CEL

Analysis of cerebral cortex from C57BL/6J and C3H/J strains at post-natal day 1 and week 11. These strains share similar collateral vessel anatomy but exhibit significantly different infarct volume. Results provide insight into molecular mechanisms modulating infarct volume.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 age, 2 other, 2 strain sets

Platform:

GPL1261

Series:

GSE46443

12 Samples

Download data: CEL

Analysis of blood collected from asthmatics immediately prior to, and two hours after, cat allergen challenge. Some asthmatics are early responders while others are dual (early plus late) responders. Results provide insight into the molecular mechanisms underlying early and dual asthmatic responses.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 10 age, 2 gender, 14 individual, 2 other, 2 protocol sets

Platform:

GPL6244

Series:

GSE40240

28 Samples

Download data: CEL